Archives of Virology

, Volume 164, Issue 10, pp 2525–2530 | Cite as

NP protein and F protein of pigeon paramyxovirus type 1 are associated with its low pathogenicity in chickens

  • Yang Song
  • Yu Pei
  • Yawen Bu
  • Wenfeng Jia
  • Guozhong ZhangEmail author
Brief Report


In this study, we investigated which structural proteins of pigeon paramyxovirus type 1 (PPMV-1) are responsible for its low pathogenicity in chickens. The results revealed that the pathogenicity of the virus is determined by multiple genes. The NP protein and F protein were found to have the strongest individual effect on virulence, and this effect further enhanced when the two proteins were expressed in combination. Our study highlights the influence of the NP and F proteins on the pathogenicity of PPMV-1 in chickens.



This study was supported by the Beijing Agriculture Innovation Consortium of Poultry Research System (BAIC04-2019). We thank Kate Fox, DPhil, from Liwen Bianji, Edanz Group China (, for editing the English text of a draft of this manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The experimental protocol, including the possibility of animal death without euthanasia, was specifically considered and approved by the Animal Welfare and Ethical Censor Committee at China Agricultural University (CAU approval number 1901–10).


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Yang Song
    • 1
  • Yu Pei
    • 1
  • Yawen Bu
    • 1
  • Wenfeng Jia
    • 1
  • Guozhong Zhang
    • 1
    Email author
  1. 1.Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary MedicineChina Agricultural UniversityBeijingChina

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