NP protein and F protein of pigeon paramyxovirus type 1 are associated with its low pathogenicity in chickens
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In this study, we investigated which structural proteins of pigeon paramyxovirus type 1 (PPMV-1) are responsible for its low pathogenicity in chickens. The results revealed that the pathogenicity of the virus is determined by multiple genes. The NP protein and F protein were found to have the strongest individual effect on virulence, and this effect further enhanced when the two proteins were expressed in combination. Our study highlights the influence of the NP and F proteins on the pathogenicity of PPMV-1 in chickens.
This study was supported by the Beijing Agriculture Innovation Consortium of Poultry Research System (BAIC04-2019). We thank Kate Fox, DPhil, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The experimental protocol, including the possibility of animal death without euthanasia, was specifically considered and approved by the Animal Welfare and Ethical Censor Committee at China Agricultural University (CAU approval number 1901–10).
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