Natural infection of captive cynomolgus monkeys (Macaca fascicularis) with hepatitis E virus genotype 4
Data on natural HEV infection of infection in monkeys are limited. We report a case of hepatitis E virus genotype 4 infection in captive non-human primates (cynomolgus monkeys) imported from Vietnam. Phylogenetic analysis demonstrated that HEV infection was not the result of spillover from single source of infection, but rather the persistent circulation of HEV-4 among cynomolgus monkeys or multiple infections by related strains from a human or swine reservoir.
We thank Saleem Kamili, Michael A. Purdy, and Jan Drobeniuc for review of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving animals
The care and use of the monkeys comply with the rules on humane care of animals and with approved experimental protocols, which were also approved by the local ethics committee. No interventions except routine blood and fecal sampling during the quarantine period were made in this study.
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