Archives of Virology

, Volume 164, Issue 5, pp 1433–1439 | Cite as

Innate immune response in astrocytes infected with herpes simplex virus 1

  • Yashvant D. Bansode
  • Debprasad Chattopadhyay
  • Bhaskar SahaEmail author
Brief Report


Herpes simplex virus 1 (HSV-1), a double-stranded DNA virus, infects epithelial surfaces and establishes latency in the central nervous system, where astrocytes are a major immune cell type. Here, we report changes that occur in the expression of pathogen recognition receptors, such as Toll-like receptors, DNA and RNA sensors, interferons, and interferon-stimulated genes, when astrocytes are infected with HSV-1 strain F. We observed upregulation of Toll-like receptors 2, 6 and 9, MDA5, and DAI along with an increase in the expression of type I interferons and interferon-stimulated genes such as IFIT1, IFIT3 and RNase L. These genes encode proteins that mediate the antiviral immune response.



Absent in melanoma 2


Cyclic GMP-AMP synthase


DNA-dependent activator of IFN-regulatory factors


DExD/H-box helicase


Eukaryotic initiation factor


Gamma-interferon-activation sites


Herpes simplex virus 1




Interferon receptor


IFN-inducible gene 204


Interferon-induced proteins with tetracopeptide repeats


Internal ribosome entry site


Interferon regulatory factor


Interferon-stimulated gene


Interferon-stimulated response element


Janus kinase


Melanoma differentiation-associated protein 5


Pathogen-associated molecular pattern


Protein kinase R


Pathogen recognition receptor


Retinoic-acid-inducible gene 1


Latent RNase


Signal transducer and activator of transcription


Toll-like receptor


Tyrosine kinase 2



Y.D.B and B.S were supported by the Department of Biotechnology and Infect-eRA (DBT, BT/In /InfecteRA /33/BS/2016-17). A visit by B.S. to Case Western Reserve University was supported by P30 AI0362 19.

Compliance with ethical standards

Conflict of interest

The authors declare that they do not have any conflict of interest.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.National Centre for Cell SciencePuneIndia
  2. 2.National Institute of Cholera and Enteric DiseasesKolkataIndia
  3. 3.Trident Academy of Creative TechnologyBhubaneswarIndia
  4. 4.National Institute of Traditional MedicineBelagaviIndia
  5. 5.Department of Molecular Biology and MicrobiologyCase Western Reserve UniversityClevelandUSA

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