Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2
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Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokines and the activation of caspases in HepG2 cells infected with YFV. We observed that interferon-α (IFN-α) expression decreased and IFN-β, transforming growth factor (TGF)-β IIIR, interleukin (IL)-6, and IL-8 expression increased in cells infected with genotype 1. In contrast, TNF-α expression increased in cells infected with genotype 2 but not with genotype 1. This provides insights into the role of cytokine regulation in yellow fever.
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All of the authors declare that they have no conflict of interest.
Research involving human participant and animals
This article does not contain any studies with human participants or animals performed by any of the authors.
- 3.Christophers R (1960) Aedes aegypti, the yellow fever mosquito. Cambridge University Press, Cambridge, p 1Google Scholar
- 5.Santos NOS, Romanos MTV, Wigg M (2008) Introdução à Virologia Humana. Guanabara-Koogan, Rio de JaneiroGoogle Scholar
- 18.Roy S, Benz F, Luedde T, Roderburg C (2015) The role of miRNAs in the regulation of inflammatory processes during hepatofibrogenesis. Hepatobiliary Surg Nutr 4:24–33. https://doi.org/10.3978/j.issn.2304-3881.2015.01.05 Google Scholar