Archives of Virology

, Volume 164, Issue 4, pp 1187–1192 | Cite as

Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2

  • Gustavo Moraes HolandaEmail author
  • Samir Mansour Morais Casseb
  • Juarez Antônio Simões Quaresma
  • Pedro Fernando Costa Vasconcelos
  • Ana Cecília Ribeiro Cruz
Brief Report


Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokines and the activation of caspases in HepG2 cells infected with YFV. We observed that interferon-α (IFN-α) expression decreased and IFN-β, transforming growth factor (TGF)-β IIIR, interleukin (IL)-6, and IL-8 expression increased in cells infected with genotype 1. In contrast, TNF-α expression increased in cells infected with genotype 2 but not with genotype 1. This provides insights into the role of cytokine regulation in yellow fever.


Compliance with ethical standards

Conflict of interest

All of the authors declare that they have no conflict of interest.

Research involving human participant and animals

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Gustavo Moraes Holanda
    • 1
    Email author
  • Samir Mansour Morais Casseb
    • 1
  • Juarez Antônio Simões Quaresma
    • 1
  • Pedro Fernando Costa Vasconcelos
    • 1
  • Ana Cecília Ribeiro Cruz
    • 1
  1. 1.Instituto Evandro ChagasAnanindeuaBrazil

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