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Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka

  • K. Yoshimatsu
  • C. D. Gamage
  • Y. D. Sarathkumara
  • T. Kulendiran
  • D. S. Muthusinghe
  • N. Nanayakkara
  • L. Gunarathne
  • K. Shimizu
  • Y. Tsuda
  • J. Arikawa
Brief Report
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Abstract

Chronic kidney disease of unknown aetiology (CKDu) reported in Sri Lanka and other countries is a mysterious and serious disease. Recently, we reported a high seroprevalence of antibodies to a hantavirus antigen among CKDu patients in Girandurukotte, Badulla district, Sri Lanka. However, the type of hantavirus with which the residents were infected was not determined. In this study, a total of 89 seropositive sera were examined to identify their serotypes using an indirect immunofluorescent antibody assay, a truncated-N-protein-based enzyme-linked immunosorbent assay, and a cross-neutralization test. These results indicated that the residents in this area were frequently infected with Thailand orthohantavirus or an antigenically related virus.

Notes

Acknowledgements

We express sincere thanks to Dr. Akio Koizumi of Kyoto University Graduate School of Medicine for helpful discussions.

Compliance with ethical standards

Ethical approval

The study was approved by the Institutional Ethical Review Committee, Faculty of Medicine, University of Peradeniya, Sri Lanka (2016/EC/64), and was also approved by the Ethical Review Committee of the Faculty of Medicine, Hokkaido University, Japan (M17-023). Patient/participant consent was obtained prior to recruitment into the study.

Conflict of interest

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, Faculty of MedicineHokkaido UniversitySapporoJapan
  2. 2.Graduate School of Infectious DiseaseHokkaido UniversitySapporoJapan
  3. 3.Department of Microbiology, Faculty of MedicineUniversity of PeradeniyaPeradeniyaSri Lanka
  4. 4.Postgraduate Institute of ScienceUniversity of PeradeniyaPeradeniyaSri Lanka
  5. 5.Nephrology and Transplantation UnitTeaching Hospital KandyKandySri Lanka
  6. 6.Renal Clinic, District HospitalGirandurukotteSri Lanka
  7. 7.Graduate School of MedicineHokkaido UniversitySapporoJapan

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