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Archives of Virology

, Volume 164, Issue 1, pp 255–260 | Cite as

Bovine viral diarrhea virus non-structural protein NS4B induces autophagosomes in bovine kidney cells

  • Yuto Suda
  • Shin Murakami
  • Taisuke HorimotoEmail author
Brief Report
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Abstract

Bovine viral diarrhea virus (BVDV) is an important pathogen in cattle that causes economic losses in livestock industries. Autophagy is an essential cell system for the maintenance of homeostasis and is induced by various triggers, including infection by viruses. BVDV infection leads to autophagy in order to enhance its replication in cells. In this study, we investigated the effect of BVDV non-structural proteins on the induction of autophagosomes. We found that NS4B alone could induce autophagosomes, suggesting a novel and important function of NS4B in BVDV replication.

Notes

Acknowledgements

We thank Dr. Atsushi Miyawaki (Riken, Japan) for the Venus/pCS2 plasmid.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest associated with this article.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent is not required because no human participants were involved in this article.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Veterinary Microbiology, Graduate School of Agricultural and Life SciencesThe University of TokyoTokyoJapan
  2. 2.Division of Viral Disease and Epidemiology, National Institute of Animal HealthNational Agriculture and Food Research OrganizationTsukubaJapan

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