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Archives of Virology

, Volume 163, Issue 12, pp 3403–3407 | Cite as

A case of incidental infection of Hepatitis E virus (HEV) genotype 1 in a domestic pig

  • Santiago Mirazo
  • Cecilia D`Albora
  • Diana Quintero Gil
  • Karina Cabrera
  • Natalia Ramos
  • Sergio Ordúz
  • Juan Arbiza
Brief Report

Abstract

Hepatitis E virus (HEV) infection involving zoonotic genotypes is a public health problem in high-income and non-endemic developing countries. Herein we report the detection of a human genotype 1 (HEV-1) strain infecting a domestic pig, which is not considered a natural reservoir of this genotype. Viral load was quantified in stool by Real-Time qPCR and sequence analyses were performed. Infectivity of the HEV-1 strain was assesed by in vitro isolation in A549 cell line. Results suggest that certain epidemiological settings might favour accidental spillover infection and thus influence the host range restriction of HEV.

Notes

Acknowledgements

Authors would like to thank MVD Gustavo Castro from Ministerio de Gandería, Agricultura y Pesca for excellent technical assistance.

Funding

This study was funded by Agencia Nacional de Investigación e Innovación (Grant FCE_2_2011_1_6731).

Compliance with ethical standards

Conflict of interest

All authors declares that they has no conflict of interest

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Ethical Committee resolution no. CBA_02356_013.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Sección VirologiaFacultad de Ciencias Universidad de la RepúblicaMontevideoUruguay
  2. 2.Facultad de CienciasUniversidad Nacional de ColombiaMedellínColombia
  3. 3.Asociación Uruguaya de Productores de CerdosMontevideoUruguay

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