A case of incidental infection of Hepatitis E virus (HEV) genotype 1 in a domestic pig
Hepatitis E virus (HEV) infection involving zoonotic genotypes is a public health problem in high-income and non-endemic developing countries. Herein we report the detection of a human genotype 1 (HEV-1) strain infecting a domestic pig, which is not considered a natural reservoir of this genotype. Viral load was quantified in stool by Real-Time qPCR and sequence analyses were performed. Infectivity of the HEV-1 strain was assesed by in vitro isolation in A549 cell line. Results suggest that certain epidemiological settings might favour accidental spillover infection and thus influence the host range restriction of HEV.
Authors would like to thank MVD Gustavo Castro from Ministerio de Gandería, Agricultura y Pesca for excellent technical assistance.
This study was funded by Agencia Nacional de Investigación e Innovación (Grant FCE_2_2011_1_6731).
Compliance with ethical standards
Conflict of interest
All authors declares that they has no conflict of interest
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Ethical Committee resolution no. CBA_02356_013.
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