Archives of Virology

, Volume 163, Issue 11, pp 3171–3172 | Cite as

Complete genome sequences of a cytophatic/noncytophatic pair of bovine viral diarrhea virus subtype 1a viruses

  • Moira Bazzucchi
  • Luigi Bertolotti
  • Monica GiammarioliEmail author
  • Gian Mario De Mia
Annotated Sequence Record


The complete genome sequences of both biotypes of a pair of bovine viral diarrhea viruses isolated from a bovid affected by mucosal disease were determined by next generation sequencing. The cytopathic virus possessed a 423-base insertion derived from bovine poly ubiquitin in the NS2/3 coding region and one nucleotide change. Both biotypes showed an additional glycosylation site in their N-terminus.



This study was supported by internal funds of the Istituto Zooprofilattico Sperimentale dell’ Umbria e delle Marche (IZS-UM).

Compliance with ethical standards

Conflict of interest

Authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


  1. 1.
    Greiser-Wilke I, Haas L, Dittmar K, Liess B, Moennig V (1993) RNA insertions and gene duplications in the nonstructural protein p 125 region of pestivirus strains and isolates in vitro and in vivo. Virology 193:977–980CrossRefPubMedGoogle Scholar
  2. 2.
    Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG (2008) The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 319:1830–1834CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Moira Bazzucchi
    • 1
  • Luigi Bertolotti
    • 2
  • Monica Giammarioli
    • 1
    Email author
  • Gian Mario De Mia
    • 1
  1. 1.Istituto Zooprofilattico Sperimentale dell’Umbria e delle MarchePerugiaItaly
  2. 2.Dipartimento di Scienze VeterinarieUniversità degli Studi di TorinoGrugliascoItaly

Personalised recommendations