Presence of rat bocavirus in oropharyngeal and fecal samples from murine rodents in China
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In this study, we detected and genetically characterized rat bocavirus (RBoV) carried in 496 murine rodents that were captured in four provinces in China between May 2015 and May 2017. RBoV-positive samples were found in all four provinces, with a total positive rate of 24.8% (123/496) in throat swabs and 58.1% (286/492) in fecal samples. Twelve nearly full-length genome sequences of RBoV were determined, and the average sequence identity was 96.2%. Phylogenetic analysis showed that RBoVs formed a distinct clade that was distinguishable from the bocaviruses discovered in humans and other animals.
We are grateful to Xue-Shan Zhong, Shao-Wei Chen, Xue-Yan Zheng, Shu-Juan Ma, Li-Na Jiang, Jin Ge, Ming Qiu, Shu-Ting Huo, Xue-Mei Ke, Wen Zhou, Xing Li, Yun Mo, Ming-Ji Cheng, Xue-Jiao Chen, Wen-Qiao He, Yu-Qi Wen and Yan-Xia Chen for their participation in collecting rodent samples.
This study was funded by National Natural Science Foundation of China (Grant no. 81373051).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study was approved by the ethics committee of the Institutional Animal Care and Use Committee of Southern Medical University.