Genetic characterization of a novel HIV-1 CRF01_AE/CRF07_BC recombinant form among men who have sex with men in Guangdong, China
- 86 Downloads
Genome recombination is a major strategy employed by HIV to generate new variants for the benefit of escaping immune surveillance. Near full-length genome phylogenic analysis was utilized to characterize HIV diversity in a male patient in Guangdong, China. The result showed a unique recombinant form (URF) composed of two circulating recombinant forms, CRF01_AE (92%) and CRF07_BC (8%), using six recombinant breakpoints, nt 2794, 3092, 4482, 5988, 7021, and 7722. The emergence of this URF indicates that HIV-1 co-infection or super-infections are common. The increasing genetic complexity of the HIV-1 epidemic in China warrants continued investigation.
This study was supported by grants from Guangdong Province Science and Technology Programme (No. 2016A020215008), Medical Scientific Research Foundation of Guangdong Province (No. A2016359), Joint-Innovative Program in Healthcare for Special Scientific Research Projects of Guangzhou (No. 201508020256), and International Collaboration Program of Natural Science Foundation of China (No. 81561128007).
Compliance of ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
Written informed consent was signed before sample collection, and the study was approved by Medical Ethics Committee of Guangzhou Eighth People’s Hospital.
- 3.Health and Family Planning Commission of Guangdong Province (2017) Report on AIDS prevention and control in 2017. http://www.gdwst.gov.cn/Pc/Index/search_show/t/all/id/17868.html [in chinese]
- 11.Li X, Ning C, He X (2013) Near full-length genome sequence of a novel HIV type 1 second-generation recombinant form (CRF01_AE/CRF07_BC) identified among men who have sex with men in Jilin, China. AIDS Res Hum Retroviruses 29:1604–1608. https://doi.org/10.1089/AID.2013.0116 CrossRefPubMedPubMedCentralGoogle Scholar