Association of CXCR2 genotype variations with HCV clearance in a Chinese population
Chemokines are known to play a vital role in guiding and regulating the immune response to viral infections. The chemokine CXC subfamily is a major subfamily in the chemokine family. Outcomes of hepatitis C virus (HCV) infection, as well as the response to treatment, depend on virus and host factors. Here we recruited chronic hepatitis C (CHC) patients to perform an association study between three single nucleotide polymorphisms (SNPs) (CXCR2 rs1126579, CXCL10 rs8878 and CXCL10 rs3921) and HCV infection outcomes and treatment responses among a Chinese population, using primarily a TaqMan assay. Multivariate logistic regression analysis was performed to identify the influencing factors on HCV infection outcome and treatment response. The results showed that subjects with the CXCR2 rs1126579 TT genotype had a significantly increased possibility of HCV spontaneous clearance (Dominant model: adjusted OR = 1.32, 95% CI = 1.06-1.64; P = 0.013). Additionally, CHC patients carrying the CXCR2 rs1126579 TT genotype were also more likely to achieve a sustained virological response (SVR) (Dominant model: adjusted OR = 0.49, 95% CI = 0.29-0.84; P = 0.010). We also established a predictive model for HCV treatment response including the CXCR2 rs1126579 SNP status, albumin (ALB) levels and baseline HCV RNA levels, which produced an area under the curve (AUC) of about 0.660. These findings highlight that variant CXCR2 rs1126579 genotypes are associated with HCV clearance within the Chinese population.
FZ, PH and RY participated in the design of the study. FZ and MY carried out the surveys and experiments. FZ performed the statistical analysis. LZ, JW, ML and YY contributed materials and analysis tools. FZ wrote the paper. All authors read and approved the final manuscript.
The current study was supported in part by National Natural Science Foundation of China (No. 81473029, 81703273, 81502853, 81473028), Natural Science Foundation of Jiangsu Province (BK2017041691, BK20151026), the Science and Technology Development Fund Key Project of Nanjing Medical University (2016NJMUZD012), Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
Compliance with ethical standards
Conflicts of interest
The authors declare no conflict of interest.
This study was approved by the Ethics Committee of Nanjing Medical University.
All subjects were provided the voluntary informed consent to participate in the study.
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