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Journal of Neural Transmission

, Volume 126, Issue 12, pp 1707–1711 | Cite as

Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

  • Thiago Wendt Viola
  • Jaqueline Bohrer Schuch
  • Diego Luiz Rovaris
  • Rafael Genovese
  • Lucca Tondo
  • Breno Sanvicente-Vieira
  • Aline Zaparte
  • Renata Basso Cupertino
  • Bruna Santos da Silva
  • Claiton Henrique Dotto Bau
  • Rodrigo Grassi-OliveiraEmail author
Psychiatry and Preclinical Psychiatric Studies - Short communication
  • 68 Downloads

Abstract

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

Keywords

SNARE complex Cocaine addiction Substance use disorders Stimulants Cognition 

Notes

Acknowledgements

This study was funded by MCT/CT-Saúde—DECIT/SCTIE/MS, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant number 466802/2014-5), Secretaria Nacional de Políticas sobre Drogas (SENAD)/Ministério da Justiça (Grant Number 822647/2015). This study was also financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior—Brasil (CAPES)—Finance Code 001. This work was partially funded by National Institute on Drug Abuse (NIDA) Grant R01DA044859. The funding source had no involvement in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. The authors would like to thank all members of the Sistema de Saúde Mãe de Deus.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Thiago Wendt Viola
    • 1
  • Jaqueline Bohrer Schuch
    • 2
  • Diego Luiz Rovaris
    • 3
    • 4
  • Rafael Genovese
    • 1
  • Lucca Tondo
    • 1
  • Breno Sanvicente-Vieira
    • 5
  • Aline Zaparte
    • 1
  • Renata Basso Cupertino
    • 4
    • 6
  • Bruna Santos da Silva
    • 4
    • 6
  • Claiton Henrique Dotto Bau
    • 4
    • 6
  • Rodrigo Grassi-Oliveira
    • 1
    Email author
  1. 1.Developmental Cognitive Neuroscience Lab, School of MedicinePontifícia Universidade Católica do Rio Grande do Sul, PUCRSPorto AlegreBrazil
  2. 2.Center for Drug and Alcohol Research, Hospital de Clínicas de Porto AlegreUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  3. 3.Department of Psychiatry, Faculdade de MedicinaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  4. 4.ADHD Outpatient Program, Adult DivisionHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  5. 5.Department of PsychologyPontifícia Universidade Católica do Rio de JaneiroRio de JaneiroBrazil
  6. 6.Department of GeneticsUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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