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Journal of Neural Transmission

, Volume 126, Issue 10, pp 1259–1271 | Cite as

Role of the protease-activated receptor 1 in regulating the function of glial cells within central and peripheral nervous system

  • Elena PompiliEmail author
  • Cinzia Fabrizi
  • Francesco Fornai
  • Lorenzo Fumagalli
High Impact Review in Neuroscience, Neurology or Psychiatry - Review Article
  • 68 Downloads

Abstract

Protease-activated receptor 1 (PAR1) is a cell surface receptor, which belongs to a family of G protein-coupled receptors and signals in response to multiple extracellular proteases. PAR1 is widely distributed in mammalian cells and tissues, including human glial cells. Within this context, PAR1 may participate to various activities promoted by glial cells. In fact, glia does not represent merely a glue in the nervous system but affects significantly various neuronal functions and activities being also significantly involved in the pathophysiology of various nervous system disorders. In this review, we summarize the current understanding of PAR1 expression and functions within glial cells both in the central and peripheral nervous system.

Keywords

Protease-activated receptor 1 Glial cells Central nervous system Peripheral nervous system 

Notes

Acknowledgements

Work performed in the author’s group was funded by PRIN to L.F., Sapienza University of Rome-Scientific Research Program 2018 to C.F. The authors thank Tommaso Savorani for developing the graphic figures.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Anatomy, Histology, Forensic Medicine and OrthopedicsSapienza University of RomeRomeItaly
  2. 2.Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly
  3. 3.IRCCS NeuromedPozzilliItaly

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