Prediction of future weight change with dopamine transporter in patients with Parkinson’s disease

  • Kyoungjune PakEmail author
  • Heeyoung Kim
  • Ju Won Seok
  • Myung Jun LeeEmail author
  • Seunghyeon Shin
  • Keunyoung Kim
  • Jae Meen Lee
  • Youngduk Seo
  • Bum Soo Kim
  • Sungmin Jun
  • In Joo Kim
Neurology and Preclinical Neurological Studies - Original Article


Fluctuating body weight is a commonly reported nonmotor feature in patients with Parkinson’s disease (PD). We hypothesised that striatal dopamine transporter (DAT) density at the time of diagnosis might play an important role in weight regulation in patients with PD. DAT density was measured from 123I-FP-CIT single-photon emission computed tomography. Region-of-interest analyses were performed to measure the specific binding of 123I-FP-CIT to DAT, and the putamen-to-caudate nucleus ratio (PCR) was calculated. Body weight was measured at baseline (W0) and at 48 months (W48). We classified subjects into three groups: weight loss, stable, and weight gain. In final analyses, 163 patients (106 men, 57 women) were included. PCR significantly differed by group in men, but not in women or across all patients. In men, PCR was slightly negatively associated with the percentage change in weight. No such correlation was found across all patients or in women. In univariate and multivariate logistic regression analyses, low PCR was associated with future weight gain in men with PD but not in women. In conclusion, striatal DAT availability at the time of diagnosis could predict subsequent weight change in men with PD.


Parkinson’s disease Dopamine plasma membrane transport proteins Neuroimaging Obesity 



PPMI, a public–private partnership, is funded by the Michael J. Fox Foundation for Parkinson’s Research and funding partners, including AbbVie, Avid, Biogen, Bristol-Myers Squibb, COVANCE, GE Healthcare, Genentech, GlaxoSmithKline, Lundbeck, Lilly, Merck, Meso Scale Discovery, Pfizer, Piramal, Roche, Sanofi Genzyme, Servier, TEVA, and UCB. This work was supported by a 2-Year Research Grant of Pusan National University.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Nuclear Medicine and Biomedical Research InstitutePusan National University HospitalBusanRepublic of Korea
  2. 2.Department of Nuclear Medicine, Kosin University Gospel HospitalKosin University College of MedicineBusanRepublic of Korea
  3. 3.Department of Nuclear MedicineChung-Ang University College of MedicineSeoulRepublic of Korea
  4. 4.Department of Neurology and Biomedical Research InstitutePusan National University HospitalBusanRepublic of Korea
  5. 5.Department of Nuclear Medicine, Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwonRepublic of Korea
  6. 6.Department of Neurosurgery and Biomedical Research InstitutePusan National University HospitalBusanRepublic of Korea
  7. 7.Department of Nuclear MedicineBusan Seongso HospitalBusanRepublic of Korea

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