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Intracranial aneurysms in patients receiving kidney transplantation for autosomal dominant polycystic kidney disease

  • Jee Yeon Kim
  • Seung Chai Jung
  • Youngmin Ko
  • Dong Hyun Kim
  • Ji Yoon Choi
  • Hyunwook Kwon
  • Joo Hee Jung
  • Young Hoon Kim
  • Duck Jong Han
  • Sung ShinEmail author
Original Article - Vascular Neurosurgery - Aneurysm
  • 17 Downloads
Part of the following topical collections:
  1. Vascular Neurosurgery – Aneurysm

Abstract

Background

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, leading to kidney failure. One of the most serious extrarenal complications of ADPKD is comorbid intracranial aneurysms. The aim of this study is to evaluate the prevalence, rupture rate, and treatment outcomes of intracranial aneurysms in ADPKD.

Methods

Adult patients with a documented diagnosis of ADPKD who received kidney transplantation at our center from January 1994 to December 2018 were included in the study. Medical history, physical examination, laboratory findings, imaging studies, and operation records were collected and analyzed from our database.

Results

Among 154 kidney transplant recipients with ADPKD, 113 (73.4%) patients were screened for intracranial aneurysms preoperatively. Twenty three patients (14.9%) had intracranial aneurysms with mean diameter size of 4.5 ± 2.7 mm. Nine patients (5.8%) experienced aneurysm rupture and the mean age at time of rupture was 34.9 ± 9.3 years. Twelve patients (52.2%) presented with multiple aneurysms. The most common aneurysm location was the bifurcation of the middle cerebral artery (34.9%). Clipping was the most common treatment in both ruptured and unruptured aneurysms.

Conclusions

Intracranial aneurysms are more frequent in patients with ADPKD, and the average age of intracranial artery rupture in patients with ADPKD is earlier than in the general population. It is necessary to consider proper evaluation and management of intracranial aneurysms when counseling ADPKD patients who will undergo kidney transplantation.

Keywords

Intracranial aneurysm Polycystic kidney disease Kidney transplantation Preoperative evaluation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. This study received approval from the institutional review board of Asan Medical Center (approval number: 2019-0310).

For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Jee Yeon Kim
    • 1
  • Seung Chai Jung
    • 2
  • Youngmin Ko
    • 1
  • Dong Hyun Kim
    • 1
  • Ji Yoon Choi
    • 1
  • Hyunwook Kwon
    • 1
  • Joo Hee Jung
    • 1
  • Young Hoon Kim
    • 1
  • Duck Jong Han
    • 1
  • Sung Shin
    • 1
    Email author
  1. 1.Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  2. 2.Department of Radiology and Research, Institute of RadiologyUniversity of Ulsan College of MedicineSeoulRepublic of Korea

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