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Acta Neurochirurgica

, Volume 161, Issue 10, pp 2049–2058 | Cite as

Predictive potential of preoperative electroencephalogram for neuropsychological change following subthalamic nucleus deep brain stimulation in Parkinson’s disease

  • Maidinamu Yakufujiang
  • Yoshinori HiguchiEmail author
  • Kyoko Aoyagi
  • Tatsuya Yamamoto
  • Midori Abe
  • Yoji Okahara
  • Masaki Izumi
  • Osamu Nagano
  • Yoshitaka Yamanaka
  • Shigeki Hirano
  • Akihiro Shiina
  • Atsushi Murata
  • Yasuo Iwadate
Original Article - Functional Neurosurgery - Movement disorders
Part of the following topical collections:
  1. Functional Neurosurgery – Movement disorders

Abstract

Background

Deep brain stimulation of the bilateral subthalamic nucleus (STN-DBS) improves motor fluctuation and severe dyskinesia in advanced Parkinson’s disease (PD). Effects on non-motor symptoms, such as neurocognitive side effects, can also influence the quality of life of both patients with PD and caregivers. Predictive quantitative factors associated with postoperative neurocognitive deterioration therefore warrant further attention. Here, we evaluated preoperative electroencephalogram (EEG) as a predictive marker for changes in neurocognitive functions after surgery.

Methods

Scalp EEG was recorded preoperatively from 17 patients with PD who underwent bilateral STN-DBS. Global relative power in the theta, alpha, and beta bands was calculated. Cognitive function was assessed with neuropsychological batteries preoperatively and 1 year after STN-DBS.

Results

Performance on the Symbol Search subtest of the WAIS III declined 1 year after DBS. The theta band was chosen for analysis with a 40% cutoff point for increased (≥ 40%) and decreased (< 40%) power. No significant differences between the two groups in baseline performance on most neuropsychological batteries were found, except for the Digit Symbol Coding subtest of the WAIS III. Changes in visual spatial functions were significantly different between groups. The increased theta band power group demonstrated a significant deterioration in performance on the WAIS III Matrix Reasoning subtest and the copy and immediate recall tasks of the Rey-Osterrieth complex figure test.

Conclusions

These findings suggest that preoperative increases in theta power are related to postoperative deterioration of visuospatial function, which indicates the predictive potential of preoperative quantitative EEG for neurocognitive changes after STN-DBS.

Keywords

Deep brain stimulation Parkinson’s disease Subthalamic nucleus Neurocognitive function Visuospatial function 

Notes

Funding

This research was partially supported by Grant-in-Aid for Scientific Research <KAKENHI> (C, 17K10885).

Compliance with ethical standards

Conflict of interest

Maidinamu Yakufujiang, Yoshinori Higuchi, Kyoko Aoyagi, Tatsuya Yamamoto, Midori Abe, Yoji Okahara, Masaki Izumi, Osamu Nagano, Yoshitaka Yamanaka, Akihiro Shiina, Atsushi Murata, and Yasuo Iwadate declare that they have no conflict of interest. Shigeki Hirano has received research grants from Eli Lilly Japan.

Research involving human participants and/or animals

This article does not contain any studies with animals performed by any of the authors.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (the Ethics Committee of Chiba University Graduate School of Medicine) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Maidinamu Yakufujiang
    • 1
  • Yoshinori Higuchi
    • 1
    Email author
  • Kyoko Aoyagi
    • 1
    • 2
  • Tatsuya Yamamoto
    • 3
  • Midori Abe
    • 4
  • Yoji Okahara
    • 2
  • Masaki Izumi
    • 1
  • Osamu Nagano
    • 2
  • Yoshitaka Yamanaka
    • 3
  • Shigeki Hirano
    • 3
  • Akihiro Shiina
    • 5
  • Atsushi Murata
    • 4
  • Yasuo Iwadate
    • 1
  1. 1.Department of Neurological SurgeryChiba University Graduate School of MedicineChiba CityJapan
  2. 2.Department of NeurosurgeryChiba Cerebral and Cardiovascular CenterChibaJapan
  3. 3.Department of NeurologyChiba University Graduate School of MedicineChibaJapan
  4. 4.Department of Rehabilitation MedicineChiba University HospitalChibaJapan
  5. 5.Division of Medical Treatment and RehabilitationChiba University Center for Forensic Mental HealthChibaJapan

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