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Acta Neurochirurgica

, Volume 161, Issue 6, pp 1085–1086 | Cite as

Lipomatosis of nerve and overgrowth syndrome: an intriguing and still unclear correlation

  • Ignazio G. VetranoEmail author
  • Luca Maria Sconfienza
  • Grazia Devigili
  • Vittoria Nazzi
Letter to the editor - Peripheral Nerves
  • 25 Downloads
Part of the following topical collections:
  1. Peripheral Nerves

Dear Editor,

We read with great interest the paper by Marek and co-authors entitled “Lipomatosis of nerve and overgrowth: is there a preference for motor (mixed) vs. sensory nerve involvement?” which recently appeared as “Online First Articles” in Acta Neurochirurgica [4].

Based on their extensive experience in this field [2, 3, 7], the authors present a summary literature review along with their Institutional cases of nerve lipomatosis (LN). This intriguing and in many ways still unclear condition consists of a fibroadipose epineurial proliferation, frequently associated with bone and soft-tissue enlargement. Due to the epineural and perineural fibrosis, nerve bundles can be strongly compressed, leading to an entrapment neuropathy [6]. Gigantism and overgrowth as asymmetric macrodactyly generally interest a part or a whole extremity, usually corresponding to the territory of distribution of a single nerve. Marek and coworkers analyzed the prevalence of overgrowth syndrome and nerves...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Chianca V, Albano D, Messina C, Cinnante CM, Triulzi FM, Sardanelli F, Sconfienza LM (2017) Diffusion tensor imaging in the musculoskeletal and peripheral nerve systems: from experimental to clinical applications. Eur Radiol Exp 1(1):12CrossRefGoogle Scholar
  2. 2.
    Mahan MA, Amrami KK, Niederhauser BD, Spinner RJ (2013) Progressive nerve territory overgrowth after subtotal resection of lipomatosis of the median nerve in the palm and wrist: a case, a review and a paradigm. Acta Neurochir 155(6):1131–1141CrossRefGoogle Scholar
  3. 3.
    Mahan MA, Amrami KK, Howe BM, Spinner RJ (2014) Segmental thoracic lipomatosis of nerve with nerve territory overgrowth. J Neurosurg 120(5):1118–1124CrossRefGoogle Scholar
  4. 4.
    Marek T, Mahan MA, Carter JM, Amrami KK, Benarroch EE, Spinner RJ (2019) Lipomatosis of nerve and overgrowth: is there a preference for motor (mixed) vs. sensory nerve involvement? Acta Neurochir:1–6Google Scholar
  5. 5.
    Sconfienza LM, Albano D, Allen G et al (2018) Clinical indications for musculoskeletal ultrasound updated in 2017 by European Society of Musculoskeletal Radiology (ESSR) consensus. Eur Radiol.  https://doi.org/10.1007/s00330-018-5474-3
  6. 6.
    Silverman TA, Enzinger FM (1985) Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases. Am J Surg Pathol 9(1):7–14CrossRefGoogle Scholar
  7. 7.
    Spinner RJ, Mahan MA, Howe BM, Prasad NK, Amrami KK (2016) A new pattern of lipomatosis of nerve: case report. J Neurosurg 126(March):933–937Google Scholar
  8. 8.
    Vetrano IG, Sconfienza LM, Albano D, Chianca V, Nazzi V (2018) Recurrence of carpal tunnel syndrome in isolated non-syndromic macrodactyly: DTI examination of a giant median nerve. Skelet Radiol.  https://doi.org/10.1007/s00256-018-3098-y

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly
  2. 2.Department of Biomedical Sciences for HealthUniversity of MilanoMilanItaly
  3. 3.IRCCS Istituto Ortopedico GaleazziMilanItaly
  4. 4.Neurological Unit 1Fondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly

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