Acta Neurochirurgica

, Volume 161, Issue 6, pp 1197–1204 | Cite as

Frontline contact aspiration thrombectomy using SOFIA catheter for acute ischemic stroke: period-to-period comparison with Penumbra catheter

  • Yong-Won Kim
  • Yang-Ha Hwang
  • Yong-Sun Kim
  • Dong-Hun KangEmail author
Original Article - Vascular Neurosurgery - Ischemia
Part of the following topical collections:
  1. Vascular Neurosurgery - Ischemia



Recent aspiration thrombectomy devices tend to have a more flexible distal tip and larger bore for easy target access and effective reperfusion. Here, this study primarily focused on the efficacy and safety of the SOFIA catheters when it was used as a frontline contact aspiration thrombectomy (CAT) tool for acute intracranial large vessel occlusion in comparison with the data from a period when the Penumbra catheter was used.


The subjects comprised 189 patients who underwent CAT (90 with Penumbra Max family and 99 with SOFIA/SOFIA plus). Patients’ data were retrospectively analyzed to evaluate overall clinical and angiographic outcomes and compared between the devices.


Baseline characteristics were similar between groups. But, intravenous alteplase was more frequently administered in the Penumbra group (43.3% vs. 29.3%, p = 0.045), while incidence of ICA occlusion was higher in SOFIA group (18.9% vs. 38.4%, p = 0.013). The modified thrombolysis in cerebral infarction 2b-3 of reperfusion was 94.4% for the Penumbra group and 92.9% for the SOFIA group (p = 0.656). The first-pass effect was more frequently achieved in the SOFIA group (20.0% vs. 39.4%, p = 0.004) and endovascular procedure time was significantly shorter (55.5 min vs. 36 min, p < 0.001). However, clinical outcomes did not differ significantly regarding mortality (11.1% vs. 6.1%, p = 0.213), hemorrhagic complications, and mRS 0–2 at 3 months (63.3% vs. 58.6%; p = 0.504).


CAT using SOFIA may be safe and comparable to thrombectomy using the Penumbra reperfusion catheter. And, the SOFIA catheter could be advantageous for rapid reperfusion and first-pass effect without any significant complications.


Acute ischemic stroke Contact aspiration thrombectomy 



Acute ischemic stroke


Contact aspiration thrombectomy


Endovascular thrombectomy


First-pass effect


Large vessel occlusion


Stent retriever thrombectomy


Compliance with ethical standards

Conflict of interests

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

For this type of study, formal consent is not required.

Informed consent

This article does not contain any studies with human participants performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Neurology, School of MedicineKyungpook National UniversityDaeguRepublic of Korea
  2. 2.Department of Radiology, School of MedicineKyungpook National UniversityDaeguRepublic of Korea
  3. 3.Department of Neurosurgery, School of MedicineKyungpook National UniversityDaeguRepublic of Korea

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