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Acta Neurochirurgica

, Volume 161, Issue 3, pp 535–543 | Cite as

Influence of pregnancy on glioma patients

  • Marie-Therese ForsterEmail author
  • Peter Baumgarten
  • Florian Gessler
  • Gabriele Maurer
  • Christian Senft
  • Elke Hattingen
  • Volker Seifert
  • Patrick N. Harter
  • Kea Franz
Original Article - Brain Tumors
  • 187 Downloads
Part of the following topical collections:
  1. Brain tumors

Abstract

Background

Data about the influence of pregnancy on progression-free survival and overall survival of glioma patients are sparse and controversial. We aimed at providing further evidence on this relation.

Methods

The course of 18 glioma patients giving birth to 23 children after tumor surgery was reviewed and compared to the course of 18 nulliparous female patients matched for tumor diagnosis including molecular markers, extent of resection, and tumor location.

Results

Tumor pathology was astrocytoma, oligodendroglioma, and ependymoma in 9, 6, and 3 patients, respectively. Time interval between tumor resection and delivery was 5.3 ± 4.4 years. All newborns were healthy after uneventful deliveries. Tumor progression was diagnosed before pregnancy in 4 patients and during pregnancy in 1 patient, and 4 patients displayed progressive disease 31.0 ± 11 months after delivery. Three of these latter patients underwent second surgery, whereas resection of recurrent tumor had been performed in 2 women before pregnancy. Among nulliparous patients, 9 women suffered from tumor progression, resulting in re-operation in 7 patients and/or further adjuvant treatment in 6 cases. Progression-free survival did not differ between patients with and patients without children (p = 0.4). Moreover, in both groups, median overall survival was not reached after a mean follow-up period of 9.7 ± 5.7 years in glioma patients who gave birth to a child and 8.9 ± 4.2 years in nulliparous glioma patients.

Conclusion

Pregnancy does not seem to influence the clinical course of glioma patients. Likewise, glioma seems not to have an impact on delivered children’s health.

Keywords

Brain tumor Glioma Matched-pairs analysis Pregnancy 

Notes

Acknowledgments

The authors thank Prof. Dr. Eva Herrmann for her help with statistics.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (ethics committee of the University Hospital Frankfurt) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Marie-Therese Forster
    • 1
    • 2
    Email author
  • Peter Baumgarten
    • 1
  • Florian Gessler
    • 1
  • Gabriele Maurer
    • 2
    • 3
  • Christian Senft
    • 1
    • 2
  • Elke Hattingen
    • 4
  • Volker Seifert
    • 1
    • 2
  • Patrick N. Harter
    • 2
    • 5
    • 6
  • Kea Franz
    • 1
    • 2
  1. 1.Department of NeurosurgeryGoethe University HospitalFrankfurt am MainGermany
  2. 2.University Cancer Center Frankfurt (UCT), Goethe University HospitalFrankfurtGermany
  3. 3.Dr. Senckenberg Institute of NeurooncologyGoethe University HospitalFrankfurt am MainGermany
  4. 4.Department of NeuroradiologyGoethe University HospitalFrankfurt am MainGermany
  5. 5.Institute of Neurology (Edinger-Institute)Goethe University HospitalFrankfurt am MainGermany
  6. 6.German Cancer Research Center DKFZ Im Neuenheimer Feld 280HeidelbergGermany

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