Acta Neurochirurgica

, Volume 161, Issue 1, pp 49–55 | Cite as

De novo cavernous malformation arising in the wall of vestibular schwannoma following stereotactic radiosurgery: case report and review of the literature

  • Leslie A. Nussbaum
  • Kevin M. KallmesEmail author
  • Ellen Bellairs
  • William McDonald
  • Eric S. NussbaumEmail author
Case Report - Brain Tumors
Part of the following topical collections:
  1. Brain tumors


We report a novel case of a radiation-induced cavernous malformation developing in a vestibular schwannoma previously treated with stereotactic radiosurgery. Eleven years after treatment, the patient presented with a large predominantly cystic lesion in the cerebellopontine angle. We performed surgery, and a solid vascular lesion was identified within the schwannoma, which was determined to be a cavernous malformation after histopathological analysis. We review the literature of radiation-induced cavernous lesions, illustrating that while rare, these lesions do pose concern as a long-term complication of brain radiation therapy. We also discuss the possibility that radiation-induced cavernous malformation-like lesions are pathologically distinct from cavernous malformations.


Cavernous malformation Radiation therapy Stereotactic radiosurgery Vestibular schwannoma 



Stereotactic radiosurgery


Radiation-induced cavernous malformation


Cavernous malformations


Cerebellopontine angle




Magnetic resonance imaging


Whole brain radiotherapy



We would like to acknowledge the editing support of Superior Medical Experts.


United Hospital Foundation provided financial support in the form of grant funding. The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards


Kevin Kallmes holds equity in and works for Superior Medical Experts.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

701_2018_3734_MOESM1_ESM.docx (63 kb)
Table S1 (DOCX 62 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.National Brain Aneurysm & Tumor CenterMinneapolisUSA
  2. 2.Duke University Law SchoolDurhamUSA
  3. 3.Minnesota OncologyTwin CitiesUSA
  4. 4.Department of PathologyAllina HealthTwin CitiesUSA

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