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Acta Neurochirurgica

, Volume 160, Issue 12, pp 2393–2396 | Cite as

Tumor-to-tumor metastasis of lung adenocarcinoma into a spinal intradural solitary fibrous tumor: a case report

  • Lazar Tosic
  • Dominik Baschera
  • Bastian Jentsch
  • Thomas Feuerstein
  • Alex Alfieri
Case Report - Tumor-Other
  • 52 Downloads
Part of the following topical collections:
  1. Tumor – Other

Abstract

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms commonly involving visceral or parietal pleura. We present the first report of tumor-to-tumor metastasis involving a pulmonary adenocarcinoma donor and an intradural SFT recipient. The patient presented with a 1 year history of diffuse back pain. A spinal intradural contrast-enhancing mass at the T9/10 level and a tumor of the lung were diagnosed radiologically. Bronchoscopic biopsy confirmed pulmonary adenocarcinoma in the right upper lung lobe. Due to deteriorating neurological status with conus medullaris syndrome, we performed a neurosurgical excision of the lesion. Histological analysis of the tumor revealed tumor-to-tumor metastasis of the adenocarcinoma to the SFT.

Keywords

Solitary fibrous tumor Tumor to tumor metastasis Pulmonary adenocarcinoma 

Abbreviations

CD34

Cluster of differentiation 34

CT

Computed tomography

EMA

Epithelial membrane antigen

MRI

Multiple resonance imaging

SFT

Solitary fibrous tumors

STAT6

Signal transducer and activator of transcription 6

TTF-1

Thyroid transcription factor-1

Notes

Acknowledgements

The authors would like to thank EDITAGE (www.editage.com) for editing the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the participant included in the study.

References

  1. 1.
    Bansil R, Walia BS, Khan Z, Abrari A (2017) Metastasis to a spinal meningioma. Surg Neurol Int 8:102.  https://doi.org/10.4103/sni.sni_466_16 CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Brunnemann RB, Ro JY, Ordonez NG, Mooney J, El-Naggar AK, Ayala AG (1999) Extrapleural solitary fibrous tumor: a clinicopathologic study of 24 cases. Mod Pathol 12:1034–1042PubMedGoogle Scholar
  3. 3.
    Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL (1968) Metastases of cancer to cancer. Cancer 22:635–643CrossRefGoogle Scholar
  4. 4.
    Chen HW, Dry SM, Seeger LL (2004) Primary lung carcinoma metastatic to a solitary fibrous tumor. Skelet Radiol 33:226–229.  https://doi.org/10.1007/s00256-003-0676-3 CrossRefGoogle Scholar
  5. 5.
    Das S, Chaudhary N, Ang LC, Megyesi JS (2017) Papillary thyroid carcinoma metastasizing to anaplastic meningioma: an unusual case of tumor-to-tumor metastasis. Brain Tumor Pathol 34:130–134.  https://doi.org/10.1007/s10014-017-0289-5 CrossRefPubMedGoogle Scholar
  6. 6.
    de Saint Aubain Somerhausen N, Rubin BP, Fletcher CD (1999) Myxoid solitary fibrous tumor: a study of seven cases with emphasis on differential diagnosis. Mod Pathol 12:463–471PubMedGoogle Scholar
  7. 7.
    Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL (2014) Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 27:390–395.  https://doi.org/10.1038/modpathol.2013.164 CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Fried BM (1930) Metastatic inoculation of a meningioma by cancer cells from a bronchiogenic carcinoma. Am J Pathol 6(47–52):41Google Scholar
  9. 9.
    Gonullu G, Sullu Y, Basoglu A, Elmali M, Karaoglanoglu M, Yucel I (2010) Metastatic breast carcinoma to solitary fibrous tumor in the lung. Indian J Cancer 47:76–78.  https://doi.org/10.4103/0019-509X.58868 CrossRefPubMedGoogle Scholar
  10. 10.
    Hanau CA, Miettinen M (1995) Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26:440–449CrossRefGoogle Scholar
  11. 11.
    Kragel C, Wei S (2011) Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report. J Med Case Rep 5:248.  https://doi.org/10.1186/1752-1947-5-248 CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Moody P, Murtagh K, Piduru S, Brem S, Murtagh R, Rojiani AM (2012) Tumor-to-tumor metastasis: pathology and neuroimaging considerations. Int J Clin Exp Pathol 5:367–373PubMedPubMedCentralGoogle Scholar
  13. 13.
    Pamphlett R (1984) Carcinoma metastasis to meningioma. J Neurol Neurosurg Psychiatry 47:561–563CrossRefGoogle Scholar
  14. 14.
    Petraki C, Vaslamatzis M, Argyrakos T, Petraki K, Strataki M, Alexopoulos C, Sotsiou F (2003) Tumor to tumor metastasis: report of two cases and review of the literature. Int J Surg Pathol 11:127–135.  https://doi.org/10.1177/106689690301100214 CrossRefPubMedGoogle Scholar
  15. 15.
    Sen SMS, McCulloch T (2010) Mesenteric solitary fibrous tumor containing metastasis from breast carcinoma: an unusual example of tumor-to-tumor metastasis. Diagn Histopathol 16:397–399CrossRefGoogle Scholar
  16. 16.
    Velez-Cubian FO, Gabordi RC, Smith PV, Toloza EM (2016) Tumor-to-tumor metastasis: an unusual case of breast cancer metastatic to a solitary fibrous tumor. J Thorac Dis 8:E374–E378.  https://doi.org/10.21037/jtd.2016.03.79 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Lazar Tosic
    • 1
  • Dominik Baschera
    • 1
  • Bastian Jentsch
    • 2
  • Thomas Feuerstein
    • 1
  • Alex Alfieri
    • 1
    • 3
  1. 1.Department of NeurosurgeryWinterthur Cantonal HospitalWinterthurSwitzerland
  2. 2.Department of PathologyWinterthur Cantonal HospitalWinterthurSwitzerland
  3. 3.Brandenburg Medical SchoolNeuruppinGermany

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