Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report

  • Pierre-Olivier ChampagneEmail author
  • Thibault Passeri
  • Sebastien Froelich
Case Report - Tumor - Meningioma
Part of the following topical collections:
  1. Tumor – Meningioma


Cyproterone acetate (CPA) is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. Nomegestrol acetate (NOMAC) is a widely used progestin-like drug that could be suggested as an alternative for patients taking CPA. We report a case of CPA-related meningioma for which relay from CPA to NOMAC led to further tumor growth and cessation of NOMAC-induced tumor shrinkage. We suggest NOMAC can have a similar effect than CPA on meningiomas. The use of NOMAC as replacement for CPA in the presence of a meningioma should be discouraged until further evidence becomes available on the role of NOMAC in such instances.


Cyproterone acetate Nomegestrol acetate Meningioma Hormone therapy 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Patient consent

The patient has consented to the submission of the case report for submission to the journal.


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© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Neurosurgery, Hôpital LariboisièreParis VII-Diderot UniversityParisFrance
  2. 2.Department of Neurosurgery, Lariboisière HospitalUniversity of Paris DiderotParisFrance

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