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Microchimica Acta

, 186:759 | Cite as

Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC

  • Myrthe Giesbers
  • Enrique Javier Carrasco-CorreaEmail author
  • Ernesto F. Simó-Alfonso
  • José Manuel Herrero-MartínezEmail author
Original Paper
  • 63 Downloads

Abstract

A (glycidyl methacrylate)-co-(ethylene glycol dimethacrylate) polymer (poly(GMA-co-EDMA)) was functionalized with metal-organic frameworks (MOF) and used as a sorbent for solid-phase extraction (SPE). The polymeric sorbent was prepared in-situ by photopolymerization in a previously wall-modified spin column, and then modified with an amino-modified MOF of type NH2-MIL-101(Cr). The sorbents were used for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs) from human urine samples. The sorbent was compared with the parent monolith and embedded approach, where the MOF particles are admixed in the polymerization mixture before the in-situ polymerization in the modified spin column. SPE is performed by percolating the sample solutions in a centrifuge, which streamlines the SPE steps. The hybrid composites were characterized by scanning electron microscopy and nitrogen intrusion porosimetry. Three NSAIDs (ketoprofen, flurbiprofen, and ibuprofen) were tested. They were eluted from the sorbent with acidified water-acetonitrile mixtures and subsequently analyzed by reversed-phase HPLC with UV detection. The detection limits varied in the range from 0.1 to 7 μg·L−1, and the precisions (relative standard deviation) were <14% in all the cases. The recoveries were between 71.0 and 78.0% in spiked urine samples.

Graphical abstract

A hybrid monolith modified with amino-modified MOF [named NH2-MIL-101(Cr)] in wall-modified spin columns was prepared. The resulting micro-extraction device was applied to the extraction and preconcentration of non-steroidal anti-inflammatory drugs.

Keywords

Sample preparation Solid-phase (micro)extraction Polymer organic monoliths Surface modification Embedded approach In-situ polymerization Microporous crystalline materials Centrifuge extraction procedure Polypropylene wall modification Photografting 

Notes

Acknowledgments

Financial support from PROMETEO/2016/145 (Conselleria de Educación, Investigación, Cultura y Deporte, Generalitat Valenciana, Spain) and RTI2018-095536-B-I00 (Ministry of Science, Innovation and Universities, Spain) is gratefully acknowledged. E. J. C.-C. thanks the Generalitat Valenciana for a VALi+D postdoctoral research contract.

Compliance with ethical standards

Conflict of interest

The authors have declared no conflict of interest.

Supplementary material

604_2019_3923_MOESM1_ESM.docx (558 kb)
ESM 1 (DOCX 558 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Myrthe Giesbers
    • 1
  • Enrique Javier Carrasco-Correa
    • 1
    Email author
  • Ernesto F. Simó-Alfonso
    • 1
  • José Manuel Herrero-Martínez
    • 1
    Email author
  1. 1.Department of Analytical Chemistry, Faculty of ChemistryUniversity of ValenciaBurjassotSpain

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