Microchimica Acta

, 186:744 | Cite as

A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection

  • Gokhan Sarp
  • Erkan YilmazEmail author
Original Paper


A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng·mL−1,1.20 ng·mL−1 and 150, respectively.

Graphical abstract

Schematic representation of the combination of flower-like Fe3O4/GO/CdSe nanodot-based magnetic solid phase extraction (MSPE) and high-performance liquid chromatography (HPLC) procedure for the extraction and analysis of ibuprofen in pharmaceuticals, water, and urine samples.


Hydrothermal synthesis Non-steroidal anti-inflammatory drug Pharmaceuticals Urine samples Water samples Magnetic separation Hummers method Nanosorbent 



This work has been supported by Erciyes University Scientific Research Projects Coordination Unit with research project FBA-2018-7761.

Compliance with ethical standards

Conflicts of interest

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3875_MOESM1_ESM.docx (239 kb)
ESM 1 (DOCX 238 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Analytical Chemistry, Faculty of PharmacyErciyes UniversityKayseriTurkey
  2. 2.ERNAM - Nanotechnology Research and Application CenterErciyes UniversityKayseriTurkey
  3. 3.Technology Research & Application Center (TAUM)Erciyes UniversityKayseriTurkey

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