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Microchimica Acta

, 186:744 | Cite as

A flower-like hybrid material composed of Fe3O4, graphene oxide and CdSe nanodots for magnetic solid phase extraction of ibuprofen prior to its quantification by HPLC detection

  • Gokhan Sarp
  • Erkan YilmazEmail author
Original Paper
  • 46 Downloads

Abstract

A flower-like Fe3O4/GO/CdSe nanodot magnetic hybrid material was produced and applied to magnetic solid-phase extraction of ibuprofen from pharmaceuticals, water, and urine samples. The material was characterized by X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy and SEM-EDX. The pH value, volume of sample solution, amount of sorbent, type and volume of elution solvent and extraction time were optimized. Following elution with acetone, ibuprofen was quantified by HPLC-DAD detection. The recoveries of ibuprofen from spiked real samples ranged between 87 and 109%, and the intra-day and inter-day relative standard deviations from 1.25 to 3.02%. The limit of detection, limit of quantification and preconcentration factor are 0.36 ng·mL−1,1.20 ng·mL−1 and 150, respectively.

Graphical abstract

Schematic representation of the combination of flower-like Fe3O4/GO/CdSe nanodot-based magnetic solid phase extraction (MSPE) and high-performance liquid chromatography (HPLC) procedure for the extraction and analysis of ibuprofen in pharmaceuticals, water, and urine samples.

Keywords

Hydrothermal synthesis Non-steroidal anti-inflammatory drug Pharmaceuticals Urine samples Water samples Magnetic separation Hummers method Nanosorbent 

Notes

Acknowledgments

This work has been supported by Erciyes University Scientific Research Projects Coordination Unit with research project FBA-2018-7761.

Compliance with ethical standards

Conflicts of interest

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3875_MOESM1_ESM.docx (239 kb)
ESM 1 (DOCX 238 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Analytical Chemistry, Faculty of PharmacyErciyes UniversityKayseriTurkey
  2. 2.ERNAM - Nanotechnology Research and Application CenterErciyes UniversityKayseriTurkey
  3. 3.Technology Research & Application Center (TAUM)Erciyes UniversityKayseriTurkey

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