Microchimica Acta

, 186:722 | Cite as

A gold electrode modified with a gold-graphene oxide nanocomposite for non-enzymatic sensing of glucose at near-neutral pH values

  • Chaohui He
  • Jiakai Wang
  • Nan Gao
  • Hanping He
  • Kailun Zou
  • Mingyu Ma
  • Yang Zhou
  • Zhiwei Cai
  • Gang ChangEmail author
  • Yunbin HeEmail author
Original Paper


A nanocomposite was prepared from gold and graphene oxide via one-step electrodeposition and used to modify the surface of a gold electrode (Au-Gr/GE) that was then applied to non-enzymatic determination of glucose. The effects of deposition time and supporting substrate on the morphology, structure, and electrochemical properties of the nanocomposite were optimized. The morphologies and crystal structures were characterized by scanning electron microscopy, transmission electron microscopy, and X-ray diffraction. The results indicate that gold nanoparticles grew on the surface of two-dimensional graphene oxide. The electrocatalytic activity of the modified electrode towards glucose oxidation was evaluated by cyclic voltammetry and amperometric methods at pH 7.4. The Au-Gr/GE, typically operated at a potential of 0.00 V (vs. Ag/AgCl), has a linear response in the 0.05–14 mM and 14–42 mM glucose concentration range, high sensitivity (604 and 267 μA cm−2 mM−1) and a low detection limit (12 μM). The modified GE was applied to quantify glucose in sweat where it exhibited excellent sensitivity and accuracy.

Graphical abstract

The gold electrode modified with a gold-graphene (Au-Gr/GE) is prepared via a direct electrodeposition. The Au-Gr/GE is used for glucose detection in the neutral solution and it can achieve the effect of non-intrusive detection.


Glucose detection Non-invasive One-step electrodeposition Sweat High sensitivity Selectivity 



The authors acknowledge the financial support from the NSFC (Nos. 21575035, 51572073, 51672074, 11774082), the NSF of Hubei Province (Nos. 2015CFA119, 2016AAA031), Wuhan application foundation frontier Project (No. 2018010401011287), and the Key Lab. of Tobacco Chemistry Foundation of Yunnan Province (No. 2016539200340109).

Compliance with ethical standards

Conflict of interest

The authors certify that there is no conflict of interest with any individual/organization for the present work.

Supplementary material

604_2019_3796_MOESM1_ESM.docx (1.1 mb)
ESM 1 (DOCX 1168 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Chaohui He
    • 1
  • Jiakai Wang
    • 1
  • Nan Gao
    • 1
  • Hanping He
    • 2
  • Kailun Zou
    • 1
  • Mingyu Ma
    • 1
  • Yang Zhou
    • 1
  • Zhiwei Cai
    • 1
  • Gang Chang
    • 1
    Email author
  • Yunbin He
    • 1
    Email author
  1. 1.Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and EngineeringHubei UniversityWuhanChina
  2. 2.Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical EngineerHubei UniversityWuhanChina

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