Advertisement

Microchimica Acta

, 186:722 | Cite as

A gold electrode modified with a gold-graphene oxide nanocomposite for non-enzymatic sensing of glucose at near-neutral pH values

  • Chaohui He
  • Jiakai Wang
  • Nan Gao
  • Hanping He
  • Kailun Zou
  • Mingyu Ma
  • Yang Zhou
  • Zhiwei Cai
  • Gang ChangEmail author
  • Yunbin HeEmail author
Original Paper
First Online:
  • 118 Downloads

Abstract

A nanocomposite was prepared from gold and graphene oxide via one-step electrodeposition and used to modify the surface of a gold electrode (Au-Gr/GE) that was then applied to non-enzymatic determination of glucose. The effects of deposition time and supporting substrate on the morphology, structure, and electrochemical properties of the nanocomposite were optimized. The morphologies and crystal structures were characterized by scanning electron microscopy, transmission electron microscopy, and X-ray diffraction. The results indicate that gold nanoparticles grew on the surface of two-dimensional graphene oxide. The electrocatalytic activity of the modified electrode towards glucose oxidation was evaluated by cyclic voltammetry and amperometric methods at pH 7.4. The Au-Gr/GE, typically operated at a potential of 0.00 V (vs. Ag/AgCl), has a linear response in the 0.05–14 mM and 14–42 mM glucose concentration range, high sensitivity (604 and 267 μA cm−2 mM−1) and a low detection limit (12 μM). The modified GE was applied to quantify glucose in sweat where it exhibited excellent sensitivity and accuracy.

Graphical abstract

The gold electrode modified with a gold-graphene (Au-Gr/GE) is prepared via a direct electrodeposition. The Au-Gr/GE is used for glucose detection in the neutral solution and it can achieve the effect of non-intrusive detection.

Keywords

Glucose detection Non-invasive One-step electrodeposition Sweat High sensitivity Selectivity 
This is a preview of subscription content, log in to check access.

Notes

Acknowledgements

The authors acknowledge the financial support from the NSFC (Nos. 21575035, 51572073, 51672074, 11774082), the NSF of Hubei Province (Nos. 2015CFA119, 2016AAA031), Wuhan application foundation frontier Project (No. 2018010401011287), and the Key Lab. of Tobacco Chemistry Foundation of Yunnan Province (No. 2016539200340109).

Compliance with ethical standards

Conflict of interest

The authors certify that there is no conflict of interest with any individual/organization for the present work.

Supplementary material

604_2019_3796_MOESM1_ESM.docx (1.1 mb)
ESM 1 (DOCX 1168 kb)

References

  1. 1.
    Nantaphol S, Watanabe T, Nomura N, Siangproh W, Chailapakul O, Einaga Y (2017) Bimetallic Pt-Au nanocatalysts electrochemically deposited on boron-doped diamond electrodes for nonenzymatic glucose detection. Biosens Bioelectron 98:76–82.  https://doi.org/10.1016/j.bios.2017.06.034 CrossRefPubMedGoogle Scholar
  2. 2.
    Li J, Yuan R, Chai Y, Che X, Li W, Zhong X (2010) Nonenzymatic glucose sensor based on a glassy carbon electrode modified with chains of platinum hollow nanoparticles and porous gold nanoparticles in a chitosan membrane. Microchim Acta 172(1–2):163–169.  https://doi.org/10.1007/s00604-010-0485-z CrossRefGoogle Scholar
  3. 3.
    Monosik R, Stredansky M, Luspai K, Magdolen P, Sturdik E (2012) Amperometric glucose biosensor utilizing FAD-dependent glucose dehydrogenase immobilized on nanocomposite electrode. Enzym Microb Technol 50(4–5):227–232.  https://doi.org/10.1016/j.enzmictec.2012.01.004 CrossRefGoogle Scholar
  4. 4.
    Zhao Y, Chu J, Li S-H, Li W-W, Liu G, Tian Y-C, Yu H-Q (2014) Non-enzymatic electrochemical detection of glucose with a gold nanowire array electrode. Electroanalysis 26(3):656–663.  https://doi.org/10.1002/elan.201300565 CrossRefGoogle Scholar
  5. 5.
    Wang L, Zhu W, Lu W, Qin X, Xu X (2018) Surface plasmon aided high sensitive non-enzymatic glucose sensor using Au/NiAu multilayered nanowire arrays. Biosens Bioelectron 111:41–46.  https://doi.org/10.1016/j.bios.2018.03.067 CrossRefPubMedGoogle Scholar
  6. 6.
    Guo MQ, Hong HS, Tang XN, Fang HD, Xu XH (2012) Ultrasonic electrodeposition of platinum nanoflowers and their application in nonenzymatic glucose sensors. Electrochim Acta 63:1–8.  https://doi.org/10.1016/j.electacta.2011.11.114 CrossRefGoogle Scholar
  7. 7.
    Lu LM, Zhang L, Qu FL, Lu HX, Zhang XB, Wu ZS, Huan SY, Wang QA, Shen GL, Yu RQ (2009) A nano-Ni based ultrasensitive nonenzymatic electrochemical sensor for glucose: enhancing sensitivity through a nanowire array strategy. Biosens Bioelectron 25(1):218–223.  https://doi.org/10.1016/j.bios.2009.06.041 CrossRefPubMedGoogle Scholar
  8. 8.
    Luo P, Zhang F, Baldwin RP (1991) Comparison of metallic electrodes for constant-potential amperometric detection of carbohydrates, amino acids and related compounds in flow systems. Anal Chim Acta 244(2):169–178CrossRefGoogle Scholar
  9. 9.
    Dhara K, Mahapatra DR (2017) Electrochemical nonenzymatic sensing of glucose using advanced nanomaterials. Microchim Acta 185(1):49.  https://doi.org/10.1007/s00604-017-2609-1
  10. 10.
    Wang H, Liu R, Li Y, Lü X, Wang Q, Zhao S, Yuan K, Cui Z, Li X, Xin S, Zhang R, Lei M, Lin Z (2018) Durable and efficient hollow porous oxide spinel microspheres for oxygen reduction. Joule 2(2):337–348.  https://doi.org/10.1016/j.joule.2017.11.016 CrossRefGoogle Scholar
  11. 11.
    He X, Luan SZ, Wang L, Wang RY, Du P, Xu YY, Yang HJ, Wang YG, Huang K, Lei M (2019) Facile loading mesoporous Co3O4 on nitrogen doped carbon matrix as an enhanced oxygen electrode catalyst. Mater Lett 244:78–82.  https://doi.org/10.1016/j.matlet.2019.01.144 CrossRefGoogle Scholar
  12. 12.
    Cherevko S, Chung CH (2010) The porous CuO electrode fabricated by hydrogen bubble evolution and its application to highly sensitive non-enzymatic glucose detection. Talanta 80(3):1371–1377.  https://doi.org/10.1016/j.talanta.2009.09.038 CrossRefPubMedGoogle Scholar
  13. 13.
    Yang J, Yu JH, Rudi Strickler J, Chang WJ, Gunasekaran S (2013) Nickel nanoparticle-chitosan-reduced graphene oxide-modified screen-printed electrodes for enzyme-free glucose sensing in portable microfluidic devices. Biosens Bioelectron 47:530–538.  https://doi.org/10.1016/j.bios.2013.03.051 CrossRefPubMedGoogle Scholar
  14. 14.
    Bi K, Bi M, Hao Y, Luo W, Cai Z, Wang X, Huang Y (2018) Ultrafine core-shell BaTiO3@SiO2 structures for nanocomposite capacitors with high energy density. Nano Energy 51:513–523.  https://doi.org/10.1016/j.nanoen.2018.07.006 CrossRefGoogle Scholar
  15. 15.
    Bi K, Wang X, Hao Y, Lei M, Dong G, Zhou J (2019) Wideband slot-coupled dielectric resonator-based filter. J Alloys Compd 785:1264–1269.  https://doi.org/10.1016/j.jallcom.2019.01.286 CrossRefGoogle Scholar
  16. 16.
    Cheng TM, Huang TK, Lin HK, Tung SP, Chen YL, Lee CY, Chiu HT (2010) (110)-exposed gold nanocoral electrode as low onset potential selective glucose sensor. ACS Appl Mater Interfaces 2(10):2773–2780.  https://doi.org/10.1021/am100432a CrossRefPubMedGoogle Scholar
  17. 17.
    Wang C-H, Song Y-Y, Zhao J-W, Xia X-H (2006) Semiconductor supported biomimetic superhydrophobic gold surfaces by the galvanic exchange reaction. Surf Sci 600(4):38–42.  https://doi.org/10.1016/j.susc.2005.12.013 CrossRefGoogle Scholar
  18. 18.
    Okutucu B, Onal S (2011) Molecularly imprinted polymers for separation of various sugars from human urine. Talanta 87:74–79.  https://doi.org/10.1016/j.talanta.2011.09.043 CrossRefPubMedGoogle Scholar
  19. 19.
    Makaram P, Owens D, Aceros J (2014) Trends in nanomaterial-based non-invasive diabetes sensing technologies. Diagnostics 4(2):27–46.  https://doi.org/10.3390/diagnostics4020027 CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Kaufman E, Lamster IB (2016) The diagnostic applications of saliva— a review. Crit Rev Oral Biol Med 13(2):197–212.  https://doi.org/10.1177/154411130201300209 CrossRefGoogle Scholar
  21. 21.
    Olarte O, Chilo J, Pelegri-Sebastia J, Barbe K Glucose detection in human sweat using an electronic nose. In: Engineering in Medicine and Biology Society, 2013. pp 1462–1465Google Scholar
  22. 22.
    Moyer J, Wilson D, Finkelshtein I, Wong B, Potts R (2012) Correlation between sweat glucose and blood glucose in subjects with diabetes. Diabetes Technol Ther 14(5):398–402.  https://doi.org/10.1089/dia.2011.0262 CrossRefPubMedGoogle Scholar
  23. 23.
    Shu H, Cao L, Chang G, He H, Zhang Y, He Y (2014) Direct electrodeposition of gold nanostructures onto glassy carbon electrodes for non-enzymatic detection of glucose. Electrochim Acta 132:524–532.  https://doi.org/10.1016/j.electacta.2014.04.031 CrossRefGoogle Scholar
  24. 24.
    Xiao G, He J, Chen X, Qiao Y, Wang F, Xia Q, Yu L, Lu Z (2019) A wearable, cotton thread/paper-based microfluidic device coupled with smartphone for sweat glucose sensing. Cellulose 26(7):4553–4562.  https://doi.org/10.1007/s10570-019-02396-y CrossRefGoogle Scholar
  25. 25.
    Shu H, Chang G, Su J, Cao L, Huang Q, Zhang Y, Xia T, He Y (2015) Single-step electrochemical deposition of high performance Au-graphene nanocomposites for nonenzymatic glucose sensing. Sensors Actuators B Chem 220:331–339.  https://doi.org/10.1016/j.snb.2015.05.094 CrossRefGoogle Scholar
  26. 26.
    Aoun SB, Dursun Z, Koga T, Bang GS, Sotomura T, Taniguchi I (2004) Effect of metal ad-layers on Au(111) electrodes on electrocatalytic oxidation of glucose in an alkaline solution. J Electroanal Chem 567(2):175–183.  https://doi.org/10.1016/j.jelechem.2003.12.022 CrossRefGoogle Scholar
  27. 27.
    Tominaga M, Shimazoe T, Nagashima M, Taniguchi I (2005) Electrocatalytic oxidation of glucose at gold nanoparticle-modified carbon electrodes in alkaline and neutral solutions. Electrochem Commun 7(2):189–193.  https://doi.org/10.1016/j.elecom.2004.12.006 CrossRefGoogle Scholar
  28. 28.
    Chang G, Shu H, Ji K, Oyama M, Liu X, He Y (2014) Gold nanoparticles directly modified glassy carbon electrode for non-enzymatic detection of glucose. Appl Surf Sci 288:524–529.  https://doi.org/10.1016/j.apsusc.2013.10.064 CrossRefGoogle Scholar
  29. 29.
    Yang H, Geng L, Zhang Y, Chang G, Zhang Z, Liu X, Lei M, He Y (2019) Graphene-templated synthesis of palladium nanoplates as novel electrocatalyst for direct methanol fuel cell. Appl Surf Sci 466:385–392.  https://doi.org/10.1016/j.apsusc.2018.10.050 CrossRefGoogle Scholar
  30. 30.
    Chen XM, Lin ZJ, Chen DJ, Jia TT, Cai ZM, Wang XR, Chen X, Chen GN, Oyama M (2010) Nonenzymatic amperometric sensing of glucose by using palladium nanoparticles supported on functional carbon nanotubes. Biosens Bioelectron 25(7):1803–1808.  https://doi.org/10.1016/j.bios.2009.12.035 CrossRefPubMedGoogle Scholar
  31. 31.
    Hrapovic S, Liu Y, Male KB, Luong JH (2004) Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes. Anal Chem 76(4):1083–1088CrossRefGoogle Scholar
  32. 32.
    Zhou Y-G, Yang S, Qian Q-Y, Xia X-H (2009) Gold nanoparticles integrated in a nanotube array for electrochemical detection of glucose. Electrochem Commun 11(1):216–219.  https://doi.org/10.1016/j.elecom.2008.11.010 CrossRefGoogle Scholar
  33. 33.
    Su L, Feng J, Zhou X, Ren C, Li H, Chen X (2012) Colorimetric detection of urine glucose based ZnFe2O4 magnetic nanoparticles. Anal Chem 84(13):5753–5758.  https://doi.org/10.1021/ac300939z CrossRefPubMedGoogle Scholar
  34. 34.
    Xia Y, Huang W, Zheng J, Niu Z, Li Z (2011) Nonenzymatic amperometric response of glucose on a nanoporous gold film electrode fabricated by a rapid and simple electrochemical method. Biosens Bioelectron 26(8):3555–3561.  https://doi.org/10.1016/j.bios.2011.01.044 CrossRefPubMedGoogle Scholar
  35. 35.
    Xu F, Cui K, Sun Y, Guo C, Liu Z, Zhang Y, Shi Y, Li Z (2010) Facile synthesis of urchin-like gold submicrostructures for nonenzymatic glucose sensing. Talanta 82(5):1845–1852.  https://doi.org/10.1016/j.talanta.2010.07.087 CrossRefPubMedGoogle Scholar
  36. 36.
    Lee Y-J, Park J-Y (2011) A coral-like macroporous gold–platinum hybrid 3D electrode for enzyme-free glucose detection. Sensors Actuators B Chem 155(1):134–139.  https://doi.org/10.1016/j.snb.2010.11.037 CrossRefGoogle Scholar
  37. 37.
    Cherevko S, Chung C-H (2009) Gold nanowire array electrode for non-enzymatic voltammetric and amperometric glucose detection. Sensors Actuators B Chem 142(1):216–223.  https://doi.org/10.1016/j.snb.2009.07.023 CrossRefGoogle Scholar
  38. 38.
    Rakhi RB, Sethupathi K, Ramaprabhu S (2009) A glucose biosensor based on deposition of glucose oxidase onto crystalline gold nanoparticle modified carbon nanotube electrode. J Phys Chem B 113(10):3190–3194CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Chaohui He
    • 1
  • Jiakai Wang
    • 1
  • Nan Gao
    • 1
  • Hanping He
    • 2
  • Kailun Zou
    • 1
  • Mingyu Ma
    • 1
  • Yang Zhou
    • 1
  • Zhiwei Cai
    • 1
  • Gang Chang
    • 1
    Email author
  • Yunbin He
    • 1
    Email author
  1. 1.Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and EngineeringHubei UniversityWuhanChina
  2. 2.Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical EngineerHubei UniversityWuhanChina

Personalised recommendations

Cite article

Buy options