Microchimica Acta

, 186:702 | Cite as

Preparation of hollow porous molecularly imprinted and aluminum(III) doped silica nanospheres for extraction of the drugs valsartan and losartan prior to their quantitation by HPLC

  • Habibeh Gholami
  • Mehrorang GhaediEmail author
  • Abbas Ostovan
  • Maryam Arabi
  • Ahmad Reza Bagheri
Original Paper


Water compatible hollow porous molecularly imprinted nanospheres (HP-MINs) have been prepared for specific recognition and extraction of the blood pressure regulating drugs valsartan (VAL) and losartan (LOS). All synthetic steps were performed in aqueous medium and without consumption of organic solvents. The morphology and functionality of the materials were characterized by FT-IR, FE-SEM, and TEM techniques. The adsorption and selectivity experiments demonstrate that the HP-MINs possess a high binding capacity, fast kinetics, excellent water dispersibility and remarkable selectivity for VAL and LOS. The HP-MINs were utilized for dispersive solid phase extraction of VAL and LOS prior to their determination by HPLC-UV. Main variables and their interactions on extraction yield were optimized by multivariate analysis with least amount of experiments. Under optimized conditions, the method has a linear response in the 5–2000 μg L−1 concentration range of both VAL and LOS. The limits of detection are 1.5 μg L−1 for VAL and 1.4 μg L−1 for LOS.

Graphical abstract

Schematic representation of dispersive solid phase extraction (d-SPE) of valsartan (VAL) and losartan (LOS) from urine sample by hollow porous molecularly imprinted nanospheres (HP-MINs).


Molecularly imprinted polymers Water compatible Experimental design methodology Dispersive solid phase extraction Urine analysis 



This work was financially supported by Graduate School and Research Council of Yasouj University.

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interest.

Supplementary material

604_2019_3794_MOESM1_ESM.doc (1.2 mb)
ESM 1 (DOC 1.21 MB)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Chemistry DepartmentYasouj UniversityYasoujIran
  2. 2.Department of Chemistry, Kerman BranchIslamic Azad UniversityKermanIran

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