Microchimica Acta

, 186:671 | Cite as

Advancements in electrochemical sensing of hydrogen peroxide, glucose and dopamine by using 2D nanoarchitectures of layered double hydroxides or metal dichalcogenides. A review

  • Ayesha Aziz
  • Muhammad Asif
  • Ghazala Ashraf
  • Muhammad Azeem
  • Irfan Majeed
  • Muhammad Ajmal
  • Junlei Wang
  • Hongfang LiuEmail author
Review Article


This review (with 105 references) describes the progress that has been made in the past few years in the use of 2D nanoarchitectures in electrochemical sensors for the clinically highly significant parameters hydrogen peroxide, glucose and dopamine. Following an introduction into the field, we summarize the improvements in electrochemical sensors that can be accomplished by using such nanomaterials, with a specific focus on sensors for in-vitro diagnostics. A further large section covers sensors based on the use of layered double hydroxides (LDHs), with subsections on sensors for hydrogen peroxide, glucose and dopamine. Dichalcogenides based electrochemical sensors are treated in next section, again with subsections on hydrogen peroxide, glucose and dopamine. We also summarize key sensor parameters including limits of detection, linear ranges and real time applications in pharmaceutical, environmental and clinical fields. The next section summarizes the work related to sensing of hydrogen peroxide released from different live cells as signalling molecule indicating cellular stress. The review concludes with a discussion of current challenges and future perspectives.

Graphical abstract

Schematic illustration of layered double hydroxides (LDHs) and dichalcogenides based electrochemical sensors for sensitive determination of hydrogen peroxide (H2O2), glucose and dopamine (DA) from biological fluids as biomarkers for early diagnosis.


2D Nanoarchitectures Electrochemical sensors Cyclic voltammetry In-vitro diagnosis Biomolecules determination Live cells Early diagnostics Cancer detection 



This work was supported by The National Key Research and Development Program of China (2018YFF0215002), National Natural Science Foundation of China (Project No. U1662114). The Foundation of Hubei Key Laboratory of Material Chemistry and Service Failure (2017), Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education (2018).

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interest.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Materials Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  2. 2.Department of ChemistryUniversity of Agriculture FaisalabadFaisalabadPakistan

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