Microchimica Acta

, 186:639 | Cite as

A nanocomposite prepared from metal-free mesoporous carbon nanospheres and graphene oxide for voltammetric determination of doxorubicin

  • Jian Liu
  • Xiangjie Bo
  • Ming ZhouEmail author
  • Liping GuoEmail author
Original Paper


A metal-free catalyst is described that consists of a composite that can be prepared from mesoporous carbon spheres (MCS) and graphene oxide (GO) under mild aqueous synthetic conditions. The reduced graphene oxide (rGO) sheets tend to aggregate, but due to the insertion of MCS, the aggregation is prevented. This leads to a larger surface area and more adsorption sites for the cancer drug doxorubicin (DOX). The π-interaction between DOX and rGO is also beneficial for the adsorption of DOX. A glassy carbon electrode (GCE) was modified with the composite and used to detect low levels of DOX, typically at a peak potential near −0.45 V (vs. Ag/AgCl). The modified GCE has a wide linear response range (10 nM - 10 μM), a low limit of detection (1.5 nM; at S/N = 3), excellent selectivity, long-term storage stability and reproducibility. It was applied to the determination of DOX in spiked serum where it gave reliable results.

Graphical abstract

Schematic representation of the preparation of mesoporous carbon spheres/reduced graphene oxide (MCS/rGO) sample, and the CV scan of doxorubicin (DOX) on MCS/rGO based nanoprode.


Electrochemical determination Electrocatalyst Carbon composites Reduced graphene oxide Anthracycline 



Financial support from National Natural Science Foundation of China (21575021) and “the Fundamental Research Funds for the Central Universities (2412019QD008)” are highly appreciated.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3754_MOESM1_ESM.docx (1.8 mb)
ESM 1 (DOCX 1867 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Faculty of ChemistryNortheast Normal UniversityChangchunPeople’s Republic of China

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