Microchimica Acta

, 186:465 | Cite as

Electrochemical sensors and biosensors based on the use of polyaniline and its nanocomposites: a review on recent advances

  • Nahid Shoaie
  • Maryam Daneshpour
  • Mostafa Azimzadeh
  • Sara Mahshid
  • Seyyed Mehdi Khoshfetrat
  • Fatemeh Jahanpeyma
  • Alieh Gholaminejad
  • Kobra OmidfarEmail author
  • Mehdi ForuzandehEmail author
Review Article


Polyaniline and its composites with nanoparticles have been widely used in electrochemical sensor and biosensors due to their attractive properties and the option of tuning them by proper choice of materials. The review (with 191 references) describes the progress made in the recent years in polyaniline-based biosensors and their applications in clinical sensing, food quality control, and environmental monitoring. A first section summarizes the features of using polyaniline in biosensing systems. A subsequent section covers sensors for clinical applications (with subsections on the detection of cancer cells and bacteria, and sensing of glucose, uric acid, and cholesterol). Further sections discuss sensors for use in the food industry (such as for sulfite, phenolic compounds, acrylamide), and in environmental monitoring (mainly pesticides and heavy metal ions). A concluding section summarizes the current state, highlights some of the challenges currently compromising performance in biosensors and nanobiosensors, and discusses potential future directions.

Graphical abstract

Schematic presentation of electrochemical sensor and biosensors applications based on polyaniline/nanoparticles in various fields of human life including medicine, food industry, and environmental monitoring. The simultaneous use of suitable properties polyaniline and nanoparticles can provide the fabrication of sensing systems with high sensitivity, short response time, high signal/noise ratio, low detection limit, and wide linear range by improving conductivity and the large surface area for biomolecules immobilization.


Sensing system Nanoparticles Clinical detection Food quality control Environmental monitoring Drugs Cancer cells Bacteria Glucose Uric acid Cholesterol Sulfite Phenolic compounds Acrylamide Pesticides Heavy metal ions 


Compliance with ethical standards

The author(s) declare that they have no competing interests.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Nahid Shoaie
    • 1
  • Maryam Daneshpour
    • 2
  • Mostafa Azimzadeh
    • 3
    • 4
    • 5
  • Sara Mahshid
    • 6
  • Seyyed Mehdi Khoshfetrat
    • 7
    • 8
  • Fatemeh Jahanpeyma
    • 1
  • Alieh Gholaminejad
    • 1
  • Kobra Omidfar
    • 7
    • 8
    Email author
  • Mehdi Foruzandeh
    • 1
    Email author
  1. 1.Department of BiotechnologyTarbiat Modares University of Medical ScienceTehranIran
  2. 2.Biotechnology Department, School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences InstituteShahid Sadoughi University of Medical SciencesYazdIran
  4. 4.Stem Cell Biology Research Center, Yazd Reproductive Sciences InstituteShahid Sadoughi University of Medical SciencesYazdIran
  5. 5.Department of Advanced Medical Sciences and Technologies, School of ParamedicineShahid Sadoughi University of Medical SciencesYazdIran
  6. 6.Department of BioengineeringMcGill UniversityQuebecCanada
  7. 7.Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical ScienceTehranIran
  8. 8.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research InstituteTehran University of Medical SciencesTehranIran

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