Microchimica Acta

, 186:454 | Cite as

Determination and removal of clenbuterol with a stable fluorescent zirconium(IV)-based metal organic framework

  • Haosen Yang
  • Bin Wang
  • Jie Cheng
  • Ruiguo Wang
  • Su Zhang
  • Shujun Dong
  • Shulin Wei
  • Peilong WangEmail author
  • Jian-Rong Li
Original Paper


A metal organic framework (MOF) based adsorbent of type UiO-66 was hydrothermally prepared and applied to simultaneous sensing and removal of the asthma drug clenbuterol. The MOF possesses a large specific surface area (1460 cm2·g−1) and a stable structure, and has a large adsorption capacity for clenbuterol (160 mg·g−1). If clenbuterol binds to the MOF, the fluorescence of the sorbent (best measured at excitation/emission wavelengths of 290/396 nm) is quenched by up to 88%. Based on these findings, a fluorometric assay has been developed for the rapid determination of clenbuterol. The adsorption equilibrium of UiO-66 for CLB can be achieved at 60 min and the adsorption efficiency is above 80%. The method has a linear response in the 4.0 to 40 ng·mL−1 concentration range, and the lower limit of detection is 0.17 μM. All of this indicates that UiO-66 is promising for simultaneous detection and the removal of CLB in water.

Graphical abstract

Schematic presentation of the detection and removal of clenbuterol in water medium by a stable fluorescent Zr(IV)-based metal organic framework. This method exhibited a large adsorption capacity for clenbuterol (160 mg/g) and low limit of detection (0.17 μM)


Clenbuterol assay Metal-organic framework Sensor Stern-Volmer plot Fluorescent quenching 



The authors would like to thank the China National Key R&D Program (2017YFC1601604), NSFC (No.21777189) and China Central Basic Research Program (Y2018PT23) for financially supporting this research.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3586_MOESM1_ESM.docx (460 kb)
ESM 1 (DOCX 460 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Haosen Yang
    • 1
  • Bin Wang
    • 2
    • 3
  • Jie Cheng
    • 1
  • Ruiguo Wang
    • 1
  • Su Zhang
    • 1
  • Shujun Dong
    • 1
  • Shulin Wei
    • 1
  • Peilong Wang
    • 1
    Email author
  • Jian-Rong Li
    • 2
  1. 1.Institute of Quality Standards and Testing Technology for Agro-productsChinese Academy of Agricultural SciencesBeijingPeople’s Republic of China
  2. 2.Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering, College of Environ-mental and Energy EngineeringBeijing University of TechnologyBeijingPeople’s Republic of China
  3. 3.College of Chemistry and Chemical Engineering, Fujian Provincial Key Laboratory of Polymer MaterialsFujian Normal UniversityFuzhouPeople’s Republic of China

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