Metal organic framework HKUST-1 modified with carboxymethyl-β-cyclodextrin for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs
- 125 Downloads
This work shows that the metal organic framework (MOF) HKUST-1 of type Cu3(BTC)2 (also referred to as MOF-199; a face-centered-cubic MOF containing nanochannels) is a most viable coating for use in enantioseparation in capillary electrochromatography (CEC). A HKUST-1 modified capillary was prepared and characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectra, elemental analysis and thermogravimetric analysis. CEC-based enantioseparation of the basic drugs propranolol (PRO), esmolol (ESM), metoprolol (MET), amlodipine (AML) and sotalol (SOT) was performed by using carboxymethyl-β-cyclodextrin as the chiral selector. Compared with a fused-silica capillary, the resolutions are improved (ESM: 1.79; MET: 1.80; PRO: 4.35; SOT: 1.91; AML: 2.65). The concentration of chiral selector, buffer pH value, applied voltage and buffer concentration were optimized, and the reproducibilities of the migration times and Rs values were evaluated.
KeywordsOpen-tubular capillary Capillary electrochromatography Enantioseparation Carboxymethyl-β-cyclodextrin Metal frame work HKUST-1 MOF-199 Mechanism Basic drugs
This work was supported by the Natural Science Foundation of Jiangsu Province (Program No.: BK20141353).
Compliance with ethical standards
The author(s) declare that they have no competing interests.
- 27.Prestipino C, Regli L, Vitillo J, Bonino F, Damin A, Lamberti C, Zecchina A, Solari P, Kongshaug K, Bordiga S (2006) Local structure of framework cu(II) in HKUST-1metallorganic framework: spectroscopic characterization upon activation and interaction with adsorbates. Chem Mater 18:1337–1346CrossRefGoogle Scholar
- 31.Qu Q, Si Y, Xuan H, Zhang K, Chen X, Ding Y, Feng S, Xu H (2017) A nanocrystalline metal organic framework confined in the fibrous pores of core-shell silica particles for improved HPLC separation. Microchem Acta 6149:1–8Google Scholar