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Microchimica Acta

, 186:462 | Cite as

Metal organic framework HKUST-1 modified with carboxymethyl-β-cyclodextrin for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs

  • Xiaodong Sun
  • Yu TaoEmail author
  • Yingxiang DuEmail author
  • Wen Ding
  • Cheng Chen
  • Xiaofei Ma
Original Paper
  • 125 Downloads

Abstract

This work shows that the metal organic framework (MOF) HKUST-1 of type Cu3(BTC)2 (also referred to as MOF-199; a face-centered-cubic MOF containing nanochannels) is a most viable coating for use in enantioseparation in capillary electrochromatography (CEC). A HKUST-1 modified capillary was prepared and characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectra, elemental analysis and thermogravimetric analysis. CEC-based enantioseparation of the basic drugs propranolol (PRO), esmolol (ESM), metoprolol (MET), amlodipine (AML) and sotalol (SOT) was performed by using carboxymethyl-β-cyclodextrin as the chiral selector. Compared with a fused-silica capillary, the resolutions are improved (ESM: 1.79; MET: 1.80; PRO: 4.35; SOT: 1.91; AML: 2.65). The concentration of chiral selector, buffer pH value, applied voltage and buffer concentration were optimized, and the reproducibilities of the migration times and Rs values were evaluated.

Graphical abstract

Schematic presentation of the preparation of a HKUST-1@capillary for enantioseparation of racemic drugs. Cu(NO3)2 and 1,3,5-benzenetricarboxylic acid (BTC) were utilized to prepare the HKUST-1@capillary. Then the capillary was applied to construct capillary electrochromatography system with carboxymethyl-β-cyclodextrin (CM-β-CD) for separation of basic racemic drugs.

Keywords

Open-tubular capillary Capillary electrochromatography Enantioseparation Carboxymethyl-β-cyclodextrin Metal frame work HKUST-1 MOF-199 Mechanism Basic drugs 

Notes

Acknowledgements

This work was supported by the Natural Science Foundation of Jiangsu Province (Program No.: BK20141353).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3584_MOESM1_ESM.docx (329 kb)
ESM 1 (DOCX 329 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education)China Pharmaceutical UniversityNanjingPeople’s Republic of China
  2. 2.State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjingPeople’s Republic of China

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