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Microchimica Acta

, 186:449 | Cite as

Polydopamine-assisted immobilization of a zinc(II)-derived metal-organic cage as a stationary phase for open-tubular capillary electrochromatography

  • Zhentao Li
  • Zhenkun Mao
  • Zilin ChenEmail author
Original Paper

Abstract

A capillary column was modified with a soluble zinc(II)-derived metal-organic cage (MOC) [Zn2L] as the stationary phase to obtain a new coating layer for use in open-tubular capillary electrochromatography. The inner surface of the capillary was first coated with a layer of polydopamine. Then, a solution of the MOC in dichloromethane was introduced into the capillary upon which it is bonded both covalently and non-covalently. The resulting coating layer on the capillary was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The results demonstrated the successful formation of the [Zn2L] modified open-tubular column. The column showed good separation performance towards neutral compounds (such as methylbenzene, ethylbenzene, n-propylbenzene and n-butylbenzene), acidic drugs (such as ibuprofen, ketoprofen, flurbiprofen and diclofenac sodium), food additives (such as parabens, vanillin and related phenolic compounds) and small biomolecules (such as nucleosides and nucleotide bases) by π-interaction and hydrophobic interaction. It also exhibited good precision, the relative standard deviations of the retention time for intra-day, inter-day runs and column-to-column being <1.6%, 2.8%, and 4.0%, respectively.

Graphical abstract

Schematic presentation of the open-tubular column modified with zinc(II)-derived metal-organic cage by polydopamine-assisted strategy onto the inner wall of capillary for electrochromatographic separations.

Keywords

MOC [Zn2L] Bio-inspired material Electrochromatographic separation Open-tubular column Drug analysis Stationary phase Food additives Biomolecules 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81872828 and 81573384).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3576_MOESM1_ESM.doc (2.6 mb)
ESM 1 (DOC 2647 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of EducationWuhan University School of Pharmaceutical SciencesWuhanChina
  2. 2.State Key Laboratory of Transducer TechnologyChinese Academy of SciencesBeijingChina

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