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Microchimica Acta

, 186:409 | Cite as

Electrochemiluminescence “turn-off” detection of curcumin via energy transfer using luminol-doped silica nanoparticles

  • Maoyu Zhao
  • Wenjing QiEmail author
  • Yuling Fu
  • Hongkun He
  • Di Wu
  • Lin Qi
  • Rong Li
Original Paper
  • 51 Downloads

Abstract

A method is presented for electrochemiluminescent (ECL) detection of the food additive curcumin via an energy transfer strategy and by using luminol-doped silica nanoparticles (luminol-NPs). The ECL emission of the luminol-NPs (peaking at 425 nm) is reduced in the presence of curcumin due to spectral overlap. The assay can be performed within 1 min, response is linear in the 0.1 to 100 µM curcumin concentration range, and the limit of detection is 32 nM. The method is selective over many ions, adenosine triphosphate, ascorbic acid, cysteine and folic acid. It was successfully applied to the determination of curcumin in spiked human serum and urine. The average recoveries range from 99.0 to 102.6%.

Graphical abstract

Electrochemiluminescence (ECL) “turn-off” detection of curcumin at levels as low as 32 nM via energy transfer using luminol-doped silica nanoparticles. No hydrogen peroxide (H2O2) is used in ECL detection which makes the luminol-NPs ECL system more stable than the conventional luminol-H2O2 ECL system.

Keywords

Electrochemiluminescence (ECL) Food additive Curcumin Energy transfer Spectral overlap Serum Urine 

Notes

Acknowledgements

This project was supported by the National Natural Science Foundation of China (No. 21505011), Chongqing Research Program of Basic Research and Frontier Technology (No. cstc2018jcyjAX0742) and Program for Top-Notch Young Innovative Talents of Chongqing Normal University (No. 02030307-00042).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3556_MOESM1_ESM.doc (150 kb)
ESM 1 Supplementary data including the effect of pH value, temperature and time on ECL detection of curcumin are freely available on the website. (DOC 149 kb)

References

  1. 1.
    Kazi M, Shariare MH, Al-bgomi M, Hussain MD, Alanazi FK (2018) Simultaneous determination of curcumin (cur) and thymoquinone (THQ) in lipid based self-nanoemulsifying systems and its application to the commercial product using UHPLC-UV-vis spectrophotometer. Curr Pharm Anal 14:277–285CrossRefGoogle Scholar
  2. 2.
    Kunati SR, Yang SM, William BM, Xu Y (2018) An LC-MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial. J Pharmaceut Biomed 156:189–198CrossRefGoogle Scholar
  3. 3.
    Liu Y, Ouyang Q, Li H, Zhang Z, Chen Q (2017) Development of an inner filter effects-based upconversion nanoparticles–curcumin nanosystem for the sensitive sensing of fluoride ion. ACS Appl Mater Interfaces 9:18314–18321CrossRefGoogle Scholar
  4. 4.
    Duan ZQ, Yin MY, Zhang CX, Song GL, Zhao SY, Yang F, Feng LP, Fan C, Zhu SY, Wang H (2018) Polyhydric polymer-loaded pyrene composites as powerful adsorbents and fluorescent probes: highly efficient adsorption and test strips-based fluorimetric analysis of curcumin in urine and plant extracts. Analyst 143:392–395CrossRefGoogle Scholar
  5. 5.
    Jain R, Haque A, Verma A (2017) Voltammetric quantification of surfactant stabilized curcumin at MWCNT/GCE sensor. J Mol Liq 230:600–607CrossRefGoogle Scholar
  6. 6.
    Zhou Q, Zhai HY, Pan YF, Li K (2017) A simple and sensitive sensor based on a molecularly imprinted polymer-modified carbon paste electrode for the determination of curcumin in foods. RSC Adv 7:22913–22918CrossRefGoogle Scholar
  7. 7.
    Zhang W, Zhu S, Luque R, Han S, Hu L, Xu G (2016) Recent development of carbon electrode materials and their bioanalytical and environmental applications. Chem Soc Rev 45:715–752CrossRefGoogle Scholar
  8. 8.
    Liu Z, Qi W, Xu G (2015) Recent advances in electrochemiluminescence. Chem Soc Rev 44:3117–3142CrossRefGoogle Scholar
  9. 9.
    Gao WY, Saqib M, Qi LM, Zhang W, Xu GB (2017) Recent advances in electrochemiluminescence devices for point-of-care testing. Curr Opin Electrochem 3:4–10CrossRefGoogle Scholar
  10. 10.
    Chinnadayyala SR, Park J, Le HTN, Santhosh M, Kadam AN, Cho S (2018) Recent advances in microfluidic paper-based electrochemiluminescence analytical devices for point-of-care testing applications. Biosens Bioelectron 126:68–81CrossRefGoogle Scholar
  11. 11.
    Muzyka K (2014) Current trends in the development of the electrochemiluminescent immunosensors. Biosens Bioelectron 54:393–407CrossRefGoogle Scholar
  12. 12.
    Han Z, Shu J, Jiang Q, Cui H (2018) Coreactant-free and label-free eletrochemiluminescence immunosensor for copeptin based on luminescent immuno-gold nanoassemblies. Anal Chem 90:6064–6070CrossRefGoogle Scholar
  13. 13.
    Deng W, Chu C, Ge S, Yu J, Yan M, Song X (2014) Electrochemiluminescence PSA assay using an ITO electrode modified with gold and palladium, and flower-like titanium dioxide microparticles as ECL labels. Microchim Acta 182:1009–1016CrossRefGoogle Scholar
  14. 14.
    Cao J-T, Liu F-R, Hou F, Peng J, Ren S-W, Liu Y-M (2018) Cathodic electrochemiluminescence behaviour of MoS2 quantum dots and its biosensing of microRNA-21. Analyst 143:3702–3707CrossRefGoogle Scholar
  15. 15.
    Zhu W, Saddam Khan M, Cao W, Sun X, Ma H, Zhang Y, Wei Q (2018) Ni(OH)2/NGQDs-based electrochemiluminescence immunosensor for prostate specific antigen detection by coupling resonance energy transfer with Fe3O4@MnO2 composites. Biosens Bioelectron 99:346–352CrossRefGoogle Scholar
  16. 16.
    Tian K, Li D, Tang T, Nie F, Zhou Y, Du J, Zheng J (2018) A novel electrochemiluminescence resonance energy transfer system of luminol-graphene quantum dot composite and its application in H2O2 detection. Talanta 185:446–452CrossRefGoogle Scholar
  17. 17.
    Zhou Y, Yu Y, Chai Y, Yuan R (2018) Electrochemical synthesis of silver nanoclusters on electrochemiluminescent resonance energy transfer amplification platform for Apo-A1 detection. Talanta 181:32–37CrossRefGoogle Scholar
  18. 18.
    Jie G, Zhang J, Wang L (2014) A novel quantum dot nanocluster as versatile probe for electrochemiluminescence and electrochemical assays of DNA and cancer cells. Biosens Bioelectron 52:69–75CrossRefGoogle Scholar
  19. 19.
    Yang X, Yuan R, Chai Y, Zhuo Y, Mao L, Yuan S (2010) Ru(bpy)3 2+-doped silica nanoparticles labeling for a sandwich-type electrochemiluminescence immunosensor. Biosens Bioelectron 25:1851–1855CrossRefGoogle Scholar
  20. 20.
    Lu H-J, Pan J-B, Wang Y-Z, Ji S-Y, Zhao W, Luo X-L, Xu J-J, Chen H-Y (2018) Electrochemiluminescence energy resonance transfer dystem between RuSi nanoparticles and hollow au nanocages for nucleic acid detection. Anal Chem 90:10434–10441CrossRefGoogle Scholar
  21. 21.
    Qi W, Wu D, Zhao J, Liu Z, Zhang W, Zhang L, Xu G (2013) Electrochemiluminescence resonance energy transfer based on Ru(phen)3 2+-doped silica nanoparticles and its application in "turn-on" detection of ozone. Anal Chem 85:3207–3212CrossRefGoogle Scholar
  22. 22.
    Qi W, Fu Y, He H, Zhao M, Wu D, Qi L, Hu L, Li R (2019) Electrochemiluminescence resonance energy transfer for both “turn-off” detection of 2,4,6-trinitrophenol and “turn-on” detection of lidocaine hydrochloride using luminol-doped silica nanoparticles. Sensors Actuators B Chem 287:445–452CrossRefGoogle Scholar
  23. 23.
    Zhang L, Dong S (2006) Electrogenerated chemiluminescence sensors using Ru(bpy)3 2+ doped in silica nanoparticles. Anal Chem 78:5119–5123CrossRefGoogle Scholar
  24. 24.
    Zhang LL, Zheng XW (2006) A novel electrogenerated chemiluminescence sensor for pyrogallol with core-shell luminol-doped silica nanoparticles modified electrode by the self-assembled technique. Anal Chim Acta 570:207–213CrossRefGoogle Scholar
  25. 25.
    Liu X, Qi W, Gao W, Liu Z, Zhang W, Gao Y, Xu G (2014) Remarkable increase in luminol electrochemiluminescence by sequential electroreduction and electrooxidation. Chem Commun 50:14662–14665CrossRefGoogle Scholar
  26. 26.
    Zhao G, Wang Y, Li X, Dong X, Wang H, Du B, Cao W, Wei Q (2018) Quenching electrochemiluminescence immunosensor based on resonance energy transfer between ruthenium (II) complex incorporated in the UiO-67 metal–organic framework and gold nanoparticles for insulin detection. ACS Appl Mater Interfaces 10:22932–22938CrossRefGoogle Scholar
  27. 27.
    Zu F, Yan F, Bai Z, Xu J, Wang Y, Huang Y, Zhou X (2017) The quenching of the fluorescence of carbon dots: a review on mechanisms and applications. Microchim Acta 184:1899–1914CrossRefGoogle Scholar
  28. 28.
    Ramírez-Herrera DE, Tirado-Guízar A, Paraguay-Delgado F, Pina-Luis G (2017) Ratiometric arginine assay based on FRET between CdTe quantum dots and Cresyl violet. Microchim Acta 184:1997–2005CrossRefGoogle Scholar
  29. 29.
    Zekavati R, Safi S, Hashemi SJ, Rahmani-Cherati T, Tabatabaei M, Mohsenifar A, Bayat M (2013) Highly sensitive FRET-based fluorescence immunoassay for aflatoxin B1 using cadmium telluride quantum dots. Microchim Acta 180:1217–1223CrossRefGoogle Scholar
  30. 30.
    Zokhtareh R, Rahimnejad M (2018) A novel sensitive electrochemical sensor based on nickel chloride solution modified glassy carbon electrode for curcumin determination. Electroanal. 30:921–927CrossRefGoogle Scholar
  31. 31.
    Baig MMF, Chen YC (2017) Bright carbon dots as fluorescence sensing agents for bacteria and curcumin. J Colloid Interface Sci 501:341–349CrossRefGoogle Scholar
  32. 32.
    Zhao X, Li F, Zhang Q, Li Z, Zhou Y, Yang J, Dong C, Wang J, Shuang S (2015) Mn-doped ZnS quantum dots with a 3-mercaptopropionic acid assembly as a ratiometric fluorescence probe for the determination of curcumin. RSC Adv 5:21504–21510CrossRefGoogle Scholar
  33. 33.
    Zhang Q, Zhang C, Li Z, Ge J, Li C, Dong C, Shuang S (2015) Nitrogen-doped carbon dots as fluorescent probe for detection of curcumin based on the inner filter effect. RSC Adv 5:95054–95060CrossRefGoogle Scholar
  34. 34.
    Liu Y, Gong XJ, Dong WJ, Zhou RX, Shuang SM, Dong C (2018) Nitrogen and phosphorus dual-doped carbon dots as a label-free sensor for curcumin determination in real sample and cellular imaging. Talanta 183:61–69CrossRefGoogle Scholar
  35. 35.
    Bian W, Wang X, Wang YK, Yang HF, Huang JL, Cai ZW, Choi MMF (2018) Boron and nitrogen co-doped carbon dots as a sensitive fluorescent probe for the detection of curcumin. Lumin J Biol Chem Lumin 33:174–180CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Chongqing Key Laboratory of Inorganic Functional Materials, College of ChemistryChongqing Normal UniversityChongqingPeople’s Republic of China
  2. 2.Huize Cigarette FactoryHongyun Honghe Tabacco (Group) Co., Ltd.HuizePeople’s Republic of China

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