Microchimica Acta

, 186:427 | Cite as

Voltammetric determination of adefovir dipivoxil by using a nanocomposite prepared from molecularly imprinted poly(o-phenylenediamine), multi-walled carbon nanotubes and carbon nitride

  • Parisa Seyed Dorraji
  • Marzieh Noori
  • Lida FotouhiEmail author
Original Paper


An electrochemical sensor for adefovir dipivoxil (ADV) detection was prepared by electropolymerization of o-phenylenediamine in the presence of ADV on a glassy carbon electrode modified with multi-walled carbon nanotubes and carbon nitride. The electrode was characterized by field emission scanning electron microscopy and differential pulse voltammetry. The performance was optimized by response surface methodology. The changes in differential pulse voltammetric peak currents of the redox probe, ferricyanide, were linear to ADV concentrations in the range from 0.1 to 9.9 μmol L-1, with the detection limit of 0.05 μmol L-1 (S/N = 3). The sensor was applied to the determination of ADV in drug formulations, human serum and urine samples. It is selective due to the use of an imprinted material, well reproducible, long-term stable, and regenerable.

Graphical abstract

By merging the unique properties of carbon nitride with intrinsic properties of MWCNTs, and molecularly imprinted polymers, a novel electrochemical sensor with selective binding sites was prepared for determination of adefovir dipivoxil in pharmaceutical and biological samples.


Voltammetric sensor Multi-walled carbon nanotubes Molecularly imprinted polymer Carbon nitride 



Financial supports of the work by Alzahra University Research Council and Iranian National Science Foundation (INSF) (grant number 97009016) are highly acknowledged.

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2019_3538_MOESM1_ESM.docx (317 kb)
ESM 1 (DOCX 317 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Parisa Seyed Dorraji
    • 1
  • Marzieh Noori
    • 1
  • Lida Fotouhi
    • 1
    Email author
  1. 1.Department of Chemistry, Faculty of Physics and ChemistryAlzahra UniversityTehranIran

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