Microchimica Acta

, 186:108 | Cite as

A core-shell structured magnetic covalent organic framework (type Fe3O4@COF) as a sorbent for solid-phase extraction of endocrine-disrupting phenols prior to their quantitation by HPLC

  • Ze-Hui Deng
  • Xia Wang
  • Xiao-Li Wang
  • Cui-Ling Gao
  • Liang Dong
  • Ming-Lin Wang
  • Ru-Song ZhaoEmail author
Original Paper


A magnetic covalent organic framework (Fe3O4@COF) with core–shell structure was fabricated at room temperature and used as an adsorbent for magnetic solid-phase extraction of polar endocrine-disrupting phenols (4-n-nonylphenol, 4-n-octylphenol, bisphenol A and bisphenol AF). The sorbent was characterized by transmission electron microscopy, FTIR, powder X-ray diffraction and other techniques. The main parameters governing the extraction efficiency were optimized. The phenols were quantified by HPLC with fluorometric detection. The method has attractive features such as low limits of detection (0.08–0.21 ng.mL−1), wide linear ranges (0.5–1000 ng.mL−1), and good repeatability (intra-day: 0.39%–4.99%; inter-day: 1.57%–5.21%). Satisfactory results were obtained when the developed method was applied to determine the four target pollutants in real world drink samples with spiked recoveries over the range of 81.3~118.0%. This indicates that the method is a powerful tool for the enrichment and determination of endocrine-disrupting phenols in drink samples.

Graphical abstract

A magnetite based covalent organic framework (Fe3O4@COFs) was synthesized with TPAB, TPA and Fe3O4. It was used for magnetic solid-phase extraction of endocrine-disrupting phenols from plastic-packaged tea drink samples coupled with liquid chromatography (LC) for determination.


Core–shell structured magnetic microspheres Fe3O4@COFs Bisphenols 4-n-nonylphenol 4-n-octylphenol Absorption Pretreatment Determination Optimization Drink samples 



This work was supported by the National Natural Science Foundation of China (21777089), the Natural Science Foundation of Shandong Province (ZR2018MB040), the Key Research and Development Program of Shandong Province (2017GSF17107 and 2018GSF117036), Shandong Provincial Key Laboratory of Test Technology for Material Chemical Safety (2018SDCLHX001), and the Shandong Province Taishan Scholar Program (ts201712063).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3198_MOESM1_ESM.doc (1.3 mb)
ESM 1 (DOC 1310 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test CenterQilu University of Technology (Shandong Academy of Sciences)JinanChina
  2. 2.College of Food Science and EngineeringShandong Agricultural UniversityTaianChina
  3. 3.Shandong Provincial Key Laboratory of Test Technology for Material Chemical SafetyShandong Institute for Product Quality InspectionJinanChina
  4. 4.National Research Center for Environmental Analysis and MeasurementBeijingChina

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