Microchimica Acta

, 186:74 | Cite as

A hollow CuOx/NiOy nanocomposite for amperometric and non-enzymatic sensing of glucose and hydrogen peroxide

  • Ling Long
  • Xiangjian Liu
  • Lulu Chen
  • Dandan Li
  • Jianbo JiaEmail author
Original Paper


The authors report that CuOx/NiOy hollow nanocomposites are an effective bifunctional catalyst capable of oxidizing glucose and reducing hydrogen peroxide. Synthesis is based on a solvothermal process and subsequent thermal treatment. The structure can be controlled by adjusting the amounts of added NiCl2 during the solvothermal etching process, and core-shell, yolk-shell or hollow structures can be obtained. The porous hollow structure composite of type CuO30/NiO90 was used to modify a glassy carbon electrode. It exhibits excellent electrocatalytic activity towards glucose oxidation in solution of pH 13, typically at a working potential of +0.60 V (vs. Ag/AgCl). This enables voltammetric sensing of glucose with (a) a low limit of detection (0.08 μM, at S/N = 3), (b) over a wide linear range (0.20 μM - 2.5 mM), and (c) high sensitivity (2043 μA·mM−1·cm−2). The sensor is reproducible, selective and stable. It can be used to detect glucose in spiked human serum. The CuO30/NiO90 composite also displays good electrocatalytic activity towards reduction of H2O2 in neutral aqueous medium, typically at an applied potential of −0.35 V. It has a detection limit of 90 nM, a sensitivity of 271.1 μA·mM−1·cm−2, and a linear detection range that extends from 0.30 μM to 9.0 mM.

Graphical abstract

CuOx/NiOy nanocomposites with three different structures were synthesized by coordinated etching precipitation method. The hollow structure CuO30/NiO90 was coated on the surface of glassy carbon electrode for the amperometric determination of glucose and hydrogen peroxide.


Hollow structure Electrochemical sensor Bifunctional electrocatalysts Glucose electro-oxidation Human serum Cu2O template Solvothermal method Controllable etching Mesoporous material Bimetal oxide 



We gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 21675147) and the Ministry of Science and Technology of China (No. 2016YFC1400601).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3183_MOESM1_ESM.docx (5.2 mb)
ESM 1 (DOCX 5345 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied ChemistryChinese Academy of SciencesJilinChina
  2. 2.University of Science and Technology of ChinaHefeiChina
  3. 3.School of Chemical and Environmental EngineeringWuyi UniversityJiangmenChina

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