Microchimica Acta

, 186:22 | Cite as

A star-shaped molecularly imprinted polymer derived from polyhedral oligomeric silsesquioxanes with improved site accessibility and capacity for enantiomeric separation via capillary electrochromatography

  • Wen-Fang Song
  • Qing-Li Zhao
  • Xiu-Jie Zhou
  • Li-Shun Zhang
  • Yan-Ping HuangEmail author
  • Zhao-Sheng LiuEmail author
Original Paper


A star-shaped molecularly imprinted coating was prepared starting from octavinyl-modified polyhedral oligomeric silsesquioxanes (Ov-POSS). It possesses a relatively open structure and has good site accessibility and a larger capacity even at lower cross-linking. The imprinted coating was prepared from S-amlodipine (S-AML) as the template and analyte, Ov-POSS as the cross-linker, and methacrylic acid as the functional monomer. The preparation and chromatographic parameters were optimized, including ratio of template to functional monomer, apparent cross-linking degree, pH value, ACN content and salt concentration in the mobile phase. The best resolution in enantiomer separation by means of capillary electrochromatography reaches a value of 33. A good recognition ability (α = 2.60) was obtained and the column efficiency for S-AML was 54,000 plates m−1. The use of Ov-POSS as a cross-linker significantly improves the column capacity and thus the detection sensitivity. The results show that Ov-POSS is an effective cross-linker for the preparation of imprinted polymers with good accessibility and large capacity.

Graphical abstract

Schematic presentation of the preparation of star-shaped imprinted polymer using octavinyl-modified polyhedral oligomeric silsesquioxanes (Ov-POSS) and by using methacrylic acid (MAA) as functional monomer. The best enantiometric resolution (33) for amlodipine (AML) can be achieved in capillary chromatography (CEC).


Star-shaped polymers Ov-POSS Molecular recognition Low cross-linking Dendrimers S-Amlodipine Chiral separation Capillary coating Imprinting effect 



This work was supported by the National Natural Science Foundation of China (Grant No. 21775109).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3151_MOESM1_ESM.doc (10.6 mb)
ESM 1 (DOC 10.6 MB)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinChina

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