Microchimica Acta

, 186:107 | Cite as

A porous organic polymer with magnetic nanoparticles on a chip array for preconcentration of platinum(IV), gold(III) and bismuth(III) prior to their on-line quantitation by ICP-MS

  • Zhenna Chen
  • Beibei Chen
  • Man He
  • Han Wang
  • Bin HuEmail author
Original Paper


A chip-based array is described for magnetic solid-phase microextraction (MSPME) of the ions of Pt, Au and Bi. Magnetic porous organic polymers (MOPs) prepared from magnetite nanoparticles and 1,3,5-tris(4-aminophenyl)benzene are introduced as a novel adsorbent. Eight solid phase extraction columns packed with MOPs were integrated in parallel on a microfluidic chip for array microextraction. After elution with a 12% (m/v) solution of cysteamine hydrochloride (pH 8.0), the eluent is introduced into an ICP-MS instrument for quantification. Under the optimized conditions, the limits of detection for Pt, Au and Bi are 8.6, 4.4 and 3.4 ng L−1, respectively. The sample throughput is 7 h−1, and the adsorption capacities are 32, 24 and 24 μg mg−1 for Pt, Au and Bi, respectively. The method was validated by the determination of Bi in a certified reference material (GSH-1A; human hair), and the values obtained coincided with the certified value. This method was also applied to the determination of Pt, Au and Bi in (spiked) urine and cell samples, and good recoveries (85.8–113%) were achieved. The method is highly sensitive and has a high throughput and a low sample/reagent consumption (with 500 HeLa cells consumed).

Graphical abstract

Schematic presentation of the magnetic packed column, microfluidic chip, and online chip-based MSPME-ICPMS system. Design sketch of the online system: microextraction unit (blue lines), microvalves (black lines), outlet channels (yellow lines), permanent magnets (red), urine and cell samples.


Diazocoupling reaction Thiol functional group Magnetic packed column Array chip-based MSPME On-line analysis ICP-MS Throughput GSH-1A reference material Cell Urine 



This work is financially supported by the National Nature Science Foundation of China (Nos. 21775113, 21575107, 21375097, 21575108), the Science Fund for Creative Research Groups of NSFC (No. 20921062), the MOE of China, and the Large-Scale Instrument and Equipment Sharing Foundation of Wuhan University (LF20181063).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3139_MOESM1_ESM.pdf (1.4 mb)
ESM 1 (PDF 1.43 mb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Chemistry, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education)Wuhan UniversityWuhanChina

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