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Microchimica Acta

, 186:107 | Cite as

A porous organic polymer with magnetic nanoparticles on a chip array for preconcentration of platinum(IV), gold(III) and bismuth(III) prior to their on-line quantitation by ICP-MS

  • Zhenna Chen
  • Beibei Chen
  • Man He
  • Han Wang
  • Bin HuEmail author
Original Paper

Abstract

A chip-based array is described for magnetic solid-phase microextraction (MSPME) of the ions of Pt, Au and Bi. Magnetic porous organic polymers (MOPs) prepared from magnetite nanoparticles and 1,3,5-tris(4-aminophenyl)benzene are introduced as a novel adsorbent. Eight solid phase extraction columns packed with MOPs were integrated in parallel on a microfluidic chip for array microextraction. After elution with a 12% (m/v) solution of cysteamine hydrochloride (pH 8.0), the eluent is introduced into an ICP-MS instrument for quantification. Under the optimized conditions, the limits of detection for Pt, Au and Bi are 8.6, 4.4 and 3.4 ng L−1, respectively. The sample throughput is 7 h−1, and the adsorption capacities are 32, 24 and 24 μg mg−1 for Pt, Au and Bi, respectively. The method was validated by the determination of Bi in a certified reference material (GSH-1A; human hair), and the values obtained coincided with the certified value. This method was also applied to the determination of Pt, Au and Bi in (spiked) urine and cell samples, and good recoveries (85.8–113%) were achieved. The method is highly sensitive and has a high throughput and a low sample/reagent consumption (with 500 HeLa cells consumed).

Graphical abstract

Schematic presentation of the magnetic packed column, microfluidic chip, and online chip-based MSPME-ICPMS system. Design sketch of the online system: microextraction unit (blue lines), microvalves (black lines), outlet channels (yellow lines), permanent magnets (red), urine and cell samples.

Keywords

Diazocoupling reaction Thiol functional group Magnetic packed column Array chip-based MSPME On-line analysis ICP-MS Throughput GSH-1A reference material Cell Urine 

Notes

Acknowledgements

This work is financially supported by the National Nature Science Foundation of China (Nos. 21775113, 21575107, 21375097, 21575108), the Science Fund for Creative Research Groups of NSFC (No. 20921062), the MOE of China, and the Large-Scale Instrument and Equipment Sharing Foundation of Wuhan University (LF20181063).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3139_MOESM1_ESM.pdf (1.4 mb)
ESM 1 (PDF 1.43 mb)

References

  1. 1.
    Merget R, Rosner G (2001) Evaluation of the health risk of platinum group metals emitted from automotive catalytic converters. Sci Total Environ 270:165–173CrossRefGoogle Scholar
  2. 2.
    Yang N, Tanner JA, Wang Z, Huang JD, Zheng BJ, Zhu NY, Sun HZ (2007) Inhibition of SARS coronavirus helicase by bismuth complexes. Chem Commun (42):4413–4415Google Scholar
  3. 3.
    Yaman M, Atici D, Bakırdere S, Akdeniz İ (2005) Comparison of trace metal concentrations in malign and benign human prostate. J Med Chem 48:630–634CrossRefGoogle Scholar
  4. 4.
    Tuzen M, Saygi K, Usta C, Soylak M (2008) Pseudomonas aeruginosa immobilized multiwalled carbon nanotubes as biosorbent for heavy metal ions. Bioresour Technol 99:1563–1570CrossRefGoogle Scholar
  5. 5.
    Faraji M, Yamini Y, Saleh A, Rezaee M, Ghambarian M, Hassani RA (2010) Nanoparticle-based solid-phase extraction procedure followed by flow injection inductively coupled plasma-optical emissionspectrometry to determine some heavy metal ions in water samples. Anal Chim Acta 659:172–177CrossRefGoogle Scholar
  6. 6.
    Hirofumi T, Takeyasu Y, Hajime O, Hisao N (2014) Determination of picomolar beryllium levels in seawater with inductively coupled plasma mass spectrometry following silica-gel preconcentration. Anal Chim Acta 852:74–81CrossRefGoogle Scholar
  7. 7.
    Chen BL, Wang LB, Xiao YQ, Fronczek FR, Xue M, Cui YJ, Qian GD (2009) A luminescent metal–organic framework with Lewis basic pyridyl sites for the sensing of metal ions. Angew Chem Int Ed 48:500–503CrossRefGoogle Scholar
  8. 8.
    Hu B, He M, Chen BB, Xia LB (2013) Liquid phase microextraction for the analysis of trace elements and their speciation. Spectrochim Acta B 86:14–30CrossRefGoogle Scholar
  9. 9.
    Liu XL, Chen BB, Zhang L, Song SY, Cai YB, He M, Hu B (2015) TiO2 nanoparticles functionalized monolithic capillary microextraction online coupled with inductively coupled plasma mass spectrometry for the analysis of Gd ion and Gd-based contrast agents in human urine. Anal Chem 87:8949–8956CrossRefGoogle Scholar
  10. 10.
    Paridhi B, Paridhi N, Dhananjaya D (2011) ‘Fab-chips’: a versatile, fabric-based platform for low-cost, rapid and multiplexed diagnostics. Lab Chip 11:2493–2499CrossRefGoogle Scholar
  11. 11.
    Wagli P, Chang YC, Homsy A, Hvozdara L, Herzig HP, De Rooij NF (2013) Microfluidic droplet-based liquid-liquid extraction and on-chip IR spectroscopy detection of cocaine in human saliva. Anal Chem 85:7558–7565CrossRefGoogle Scholar
  12. 12.
    Zhang J, Chen BB, Wang H, He M, Hu B (2017) Facile Chip-based Array monolithic microextraction system online coupled with ICPMS for fast analysis of trace heavy metals in biological samples. Anal Chem 89:6878–6885CrossRefGoogle Scholar
  13. 13.
    Kim KS, Park JK (2005) Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel. Lab Chip 5:657–664CrossRefGoogle Scholar
  14. 14.
    Barbee K, Huang XH (2008) Magnetic assembly of high-density DNA arrays for genomic analyses. Anal Chem 80:2149–2154CrossRefGoogle Scholar
  15. 15.
    Slovakova M, Minc N, Bilkova Z, Smadja C, Faigle W, Futterer C, Taverna M, Viovy JL (2005) Use of self assembled magnetic beads for on-chip protein digestion. Lab Chip 5:935–942CrossRefGoogle Scholar
  16. 16.
    Yi CQ, Li CW, Ji SL, Yang MS (2006) Microfluidics technology for manipulation and analysis of biological cells. Anal Chim Acta 560:1–23CrossRefGoogle Scholar
  17. 17.
    Chen BB, Heng SJ, Peng HY, Hu B, Yu X, Zhang ZL, Pang DW, Yue X, Zhu Y (2010) Magnetic solid phase microextraction on a microchip combined with electrothermal vaporization-inductively coupled plasma mass spectrometry for determination of cd, hg and Pb in cells. J Anal At Spectrom 25:1931–1938CrossRefGoogle Scholar
  18. 18.
    Yu XX, Chen BB, He M, Wang H, Hu B (2018) Chip-based magnetic solid phase microextraction coupled with ICP-MS for the determination of cd and se in HepG2 cells incubated with CdSe quantum dots. Talanta 179:279–284CrossRefGoogle Scholar
  19. 19.
    Wang H, Chen BB, Zhu SQ, Yu XX, He M, Hu B (2016) Chip-based magnetic solid-phase microextraction online coupled with MicroHPLC-ICPMS for the determination of mercury species in cells. Anal Chem 88:796–802CrossRefGoogle Scholar
  20. 20.
    Wang H, Wu ZK, Chen BB, He M, Hu B (2015) Chip-based array magnetic solid phase microextraction on-line coupled with inductively coupled plasma mass spectrometry for the determination of trace heavy metals in cells. Analyst 140:5619–5626CrossRefGoogle Scholar
  21. 21.
    Chen BB, Hu B, He M, Huang Q, Zhang Y, Zhang X (2013) Speciation of selenium in cells by HPLC-ICP-MS after (on-chip) magnetic solid phase extraction. J Anal At Spectrom 28:334–343CrossRefGoogle Scholar
  22. 22.
    Ji G, Yang Z, Zhang H, Zhao Y, Yu B, Ma Z, Liu Z (2016) Hierarchically Mesoporous O-Hydroxyazobenzene polymers: synthesis and their applications in CO2 capture and conversion. Angew Chem Int Ed 55:9685–9689CrossRefGoogle Scholar
  23. 23.
    Huang LJ, Peng CY, Cheng Q, He M, Chen BB, Hu B (2017) Thiol-functionalized magnetic porous organic polymers for highly efficient removal of mercury. Ind Eng Chem Res 56:13696–13703CrossRefGoogle Scholar
  24. 24.
    Jalilian N, Ebrahimzadeh H, Asgharinezhad AA, Molaei K (2017) Extraction and determination of trace amounts of gold(III), palladium(II), platinum(II) and silver(I) with the aid of a magnetic nanosorbent made from Fe3O4-decorated and silica-coated graphene oxide modified with a polypyrrole-polythiophene copolymer. Microchim Acta 184(7):2191–2200CrossRefGoogle Scholar
  25. 25.
    Zhou S, Song N, Lv X, Jia Q (2017) Magnetic dual task-specific polymeric ionic liquid nanoparticles for preconcentration and determination of gold, palladium and platinum prior to their quantitation by graphite furnace AAS. Microchim Acta 184:3497–3504CrossRefGoogle Scholar
  26. 26.
    U.S. Environmental Protection Agency, Office of Sci Technol (2001) Trace elements in water, solids, and biosolids by inductively coupled plasma-atomic emission spectrometry. EPA. Method 200.7, Section 9.5, pp 31Google Scholar
  27. 27.
    Murphy PJ, LaGrange MS (1998) Raman spectroscopy of gold chloro-hydroxy speciation in fluids at ambient temperatureand pressure: a re-evaluation of the effects of pH and chloride concentration. Geochimi Cosmochim Ac 62:3515–3526CrossRefGoogle Scholar
  28. 28.
    Spieker WA, Liu J, Miller JT, Kropf AJ, Regalbuto JR (2002) An EXAFS study of the co-ordination chemistry of hydrogen hexachloroplatinate(IV). Speciation in aqueous solution Appl Catal A-Gen 232:219–235CrossRefGoogle Scholar
  29. 29.
    Caroli S, Alimonti A, Coni E, Petrucci F, Senofonte O, Violante N (1994) The assessment of reference values for elements in human biological tissues and fluids: a systematic review. Crit Rev Anal Chem 24:363–398CrossRefGoogle Scholar
  30. 30.
    Alonso Castillo ML, García de Torres A, Vereda Alonso E, Siles Cordero MT, Cano Pavón JM (2012) Multi-element determination of Pt, Pd and Ir traces in environmental samples by ICP-MS after pre-concentration. Talanta 99:853–858CrossRefGoogle Scholar
  31. 31.
    Zhang J, Chen BB, Wang H, Huang X, He M, Hu B (2016) Chip-based monolithic microextraction combined with ICP-MS for the determination of bismuth in HepG2 cells. J Anal At Spectrom 31:1391–1399CrossRefGoogle Scholar
  32. 32.
    Vojoudi H, Badiei A, Banaei A, Bahar S, Karimi S, Ziarani GM, Ganjali MR (2017) Extraction of gold, palladium and silver ions using organically modified silica-coated magnetic nanoparticles and silica gel as a sorbent. Microchim Acta 184:3859–3866CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Chemistry, Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education)Wuhan UniversityWuhanChina

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