Microchimica Acta

, 186:9 | Cite as

A non-enzymatic voltammetric xanthine sensor based on the use of platinum nanoparticles loaded with a metal-organic framework of type MIL-101(Cr). Application to simultaneous detection of dopamine, uric acid, xanthine and hypoxanthine

  • Li Zhang
  • Shaobin Li
  • Jianjiao Xin
  • Huiyuan MaEmail author
  • Haijun Pang
  • Lichao Tan
  • Xinming Wang
Original Paper


A Cr-based metal-organic framework MIL-101(Cr) was used to load platinum nanoparticles (PtNPs) that were placed on a glassy carbon electrode (GCE). The modified GCE was used as a non-enzymatic xanthine sensor. Compared to bare GCE, it requires a strongly decreased working potential and an increased signal current for xanthine oxidation. This is due to the crystalline ordered structure and large specific surface of the MIL-101(Cr), and to the high conductivity of the Pt NPs. Differential pulse voltammetry (DPV) shows the sensor to have a wide linear range (0.5 – 162 μM), a low detection limit (0.42 μM), and high selectivity. It was applied to the simultaneous determination of dopamine, uric acid, xanthine and hypoxanthine at working potentials of 0.13, 0.28, 0.68 and 1.05 V, respectively (vs. Ag/AgCl) and to quantify xanthine in spiked serum samples.

Graphical abstract

This is the first report of non-enzymatic xanthine electrochemical sensor based on metal-organic framework loaded with nanoparticles.


Metal-organic frameworks Metal nanoparticles Electrochemistry Non-enzymatic sensor Glassy carbon electrode Cyclic voltammetry Differential pulse voltammetry Electrochemical impedance spectroscopy Human serum Standard addition method 



This work was financially supported by the NSF of China (21671049, 51572063, 21603113 and 21701037), postdoctoral science foundation, China (2017 M611380).

Compliance with ethical standards

The author(s) declare that they have no competing interests.

Supplementary material

604_2018_3128_MOESM1_ESM.doc (1.6 mb)
ESM 1 (DOC 1.55 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Li Zhang
    • 1
  • Shaobin Li
    • 1
    • 2
  • Jianjiao Xin
    • 1
  • Huiyuan Ma
    • 1
    Email author
  • Haijun Pang
    • 1
  • Lichao Tan
    • 1
  • Xinming Wang
    • 1
  1. 1.School of Materials Science and Engineering, College of Chemical and Environmental EngineeringHarbin University of Science and TechnologyHarbinChina
  2. 2.College of Materials Science and Engineering, Heilongjiang Provincial Key Laboratory of Polymeric Composite MaterialsQiqihar UniversityQiqiharChina

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