Impact of the preoperative bone mineral density on the outcomes after resection of pancreatic cancer
The aim of this study is to evaluate the correlation between bone mineral density (BMD) and other body composition markers, as well as, the impact of preoperative BMD on the surgical outcomes after resection of pancreatic cancer.
This retrospective study included 275 patients who underwent surgical resection of pancreatic cancer in our institute between 2003 and 2016. Patients were divided according to BMD into low and normal groups and their postoperative outcomes were compared. Risk factors for mortality and tumor recurrence were also evaluated.
Patients with low BMD were older (P < 0.001), had a higher intramuscular adipose tissue content (P = 0.011) and higher visceral fat area (P = 0.003). The incidence of postoperative pancreatic fistula (POPF) (grade ≥ B) was higher in the low BMD group. No significant difference was observed between the two groups regarding overall survival and recurrence-free survival and low BMD was not a risk factor for mortality or tumor recurrence after resection of pancreatic cancer.
A low preoperative BMD was not found to be a risk factor for mortality or tumor recurrence after resection of pancreatic cancer; however, it was associated with a higher incidence of clinically relevant POPF.
KeywordsBone mineral density Sarcopenia Pancreatic cancer Survival Recurrence
Body mass index
Bone mineral density
- CA 19.9
Carbohydrate antigen 19.9
Dual-energy X-ray absorptiometry
Intramuscular adipose tissue content
Modified Glasgow prognostic score
Psoas muscle index
Prognostic nutritional index
Postoperative pancreatic fistula
Skeletal mass index
Union for International Cancer Control
Visceral to subcutaneous adipose tissue area ratio
Compliance with ethical standards
Conflict of interest
The authors declare no conflicts of interest in association with the present study.
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