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Safety and efficacy of hydroxyethyl starch 6% 130/0.4/9 solution versus 5% human serum albumin in thoracic esophagectomy with 3-field lymph nodes dissection

  • Takeo FujitaEmail author
  • Naoya Okada
  • Yasumasa Horikiri
  • Takuji Sato
  • Hisashi Fujiwara
  • Shuhei Mayanagi
  • Jun Kanamori
  • Hiroyuki Yamamoto
  • Hiroyuki Daiko
Original Article
  • 25 Downloads

Abstract

Purpose

We investigated the safety and efficacy of administering hydroxyethyl starch 6% 130/0.4/9 (HES130/0.4/9) versus 5% human serum albumin (HSA), perioperatively, to patients undergoing thoracic esophagectomy with 3-field lymph-node dissection for esophageal cancer.

Methods

The subjects of this study were 262 patients, scheduled to undergo thoracic esophagectomy for esophageal cancer, who were assigned to one of two groups based on the fluid replacement therapy. We compared the intraoperative and immediate postoperative hemodynamics and incidence of complications in the two groups.

Results

Neither group suffered any adverse events. No significant differences were observed in systolic/diastolic blood pressure, heart rate, incidence of postoperative complications, postoperative urine output, or serum creatinine levels, between the groups. A mild postoperative increase (×1.5 increase) in serum creatinine levels was seen in 9.5% and 9.5% of patients in the HSA and HES130/0.4/9 groups, respectively (p = 0.99), and a moderate postoperative increase (×2.0 increase) was seen in 4.4% and 3.1%, respectively (p = 0.84). Univariate and multivariate analyses revealed that the administration of hydroxyethyl starch was not associated with a postoperative increase in serum creatinine levels.

Conclusion

Hydroxyethyl starch 6% 130/0.4/9 was well tolerated and comparable to albumin with respect to its effect on renal function during thoracic esophagectomy with 3-field lymph-node dissection.

Keywords

Esophageal cancers Esophagectomy Hydroxyethyl starch 6% 130/0.4/9 

Notes

Acknowledgements

We thank the members of the Division of Esophageal Surgery for their critical discussion of our manuscript. We also thank the members of the Division of Gastrointestinal Oncology for reviewing and discussing the study.

Author contributions

All persons who meet authorship criteria are listed as authors, and all authors certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, writing, or revision of the manuscript.

Compliance with ethical standards

Conflict of interest

There are no financial relationships or support that may pose a conflict of interest.

Disclosure

The content has not been published or submitted for publication elsewhere.

Supplementary material

595_2018_1752_MOESM1_ESM.tif (105 kb)
Supplementary material 1 (TIF 105 KB)

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Takeo Fujita
    • 1
    Email author
  • Naoya Okada
    • 1
  • Yasumasa Horikiri
    • 1
  • Takuji Sato
    • 1
  • Hisashi Fujiwara
    • 1
  • Shuhei Mayanagi
    • 1
  • Jun Kanamori
    • 1
  • Hiroyuki Yamamoto
    • 2
  • Hiroyuki Daiko
    • 1
  1. 1.Division of Esophageal SurgeryNational Cancer Center Hospital EastKashiwaJapan
  2. 2.Division of AnesthesiologyNational Cancer Center Hospital EastKashiwaJapan

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