Abstract
We report a rare case of granulocyte-colony stimulating factor (G-CSF)-producing undifferentiated carcinoma of the ascending colon. A 52-year-old Japanese man presented with a rapidly growing, aggressive abdominal tumor, and severe leukocytosis (63 000/mm3). The serum level of G-CSF was remarkably elevated to 640 pg/ml (normal, <18.1 pg/ml). The patient underwent palliative cytoreductive surgery for ascending colon carcinoma with lymph node and liver metastases. Histological examination revealed an undifferentiated carcinoma of the ascending colon. The tumor cells were positive for G-CSF on immunohistochemical staining. The leukocyte counts and G-CSF level decreased after surgery. Thus, we diagnosed G-CSF-producing colon carcinoma. His general condition deteriorated rapidly and he died of residual tumor growth on postoperative day 24.
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Kimura N, Niho Y, Yanase T. A high level of colony-stimulating activity in a lung cancer patient with extensive leucocytosis and the establishment of a CAS-producing cell line. Scand J Hematol 1982;28:417–427.
Obara T, Ito Y, Kodama T, Fujimoto Y, Mizoguchi H, Oshimi K, et al. A case of gastric carcinoma associated with excessive granulocytosis. Production of a colony-stimulating factor by the tumor. Cancer 1985;56:782–788.
Aita K, Seki K. Carcinosarcoma of the liver producing granulocyte-colony stimulating factor. Pathol Int 2006;56:413–419.
Ikeda T, Ohgaki K, Miura M, Aishima S, Shimizu T, Maehara Y. Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: report of a case. Surg Today 2005;35:590–593.
Wu M, Cini JK, Yunis AA. Purification of a colony stimulating factor from cultured pancreatic carcinoma cells. J Biol Chem 1979;254:6626–6628.
Katsumata D, Fukui H, Ono Y, Ichikawa K, Tomita S, Imura J, et al. Depth of tumor invasion in locally advanced rectal cancer correlates with patients’ prognosis: The usefulness of elastic stain for its measurement. Surg Today 2008;38:115–122.
Kojima K, Nakashima F, Boku A, Muroishi Y, Nakanishi I, Oda Y. Clinicopathological study of involvement of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor in non-lymphohematopoietic malignant tumors accompanied by leukocytosis. Histol Histopathol 2002;17:1005–1016.
Asano S, Urabe A, Okabe T, Sano N, Kondo Y. Demonstration of granulopoietic factors in the plasma of nude mice with human lung cancer and in the tumor. Blood 1977;49:845–852.
Kakinoki K, Takemori Y, Noda Y, Hoso M. An autopsy case of intrahepatic cholangiocarcinoma producing granulocyte-colony stimulating factor (in Japanese with English abstract). Nippon Shokakibyo Gakkai Zasshi (J Jpn Soc Gastroenterol) 2000;97:1165–1169.
Uzumaki H, Okabe T, Sasaki N, Hagiwara K, Takaku F, Tobita M, et al. Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells. Proc Natl Acad Sci USA 1989;86:9323–9326.
Yang X, Liu F, Xu Z, Chen C, Wu X, Li G, et al. Expression of granulocyte colony stimulating factor receptor in human colorectal cancer. Postgrad Med J 2005;81:333–337.
Tachibana M, Miyakawa A, Tazaki H, Nakamura K, Kubo A, Hata J, et al. Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor. Cancer Res 1995;55:3438–3443.
Natori T, Sata M, Washida M, Hirata Y, Nagai R, Makuuchi M. G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun 2002;297:1058–1061.
Aeed PA, Nakajima M, Welch DR. The role of polymorphonuclear leukocytes (PMN) on the growth and metastatic potential of 13762NF mammary adenocarcinoma cells. Int J Cancer 1988;42:748–759.
Weitzman SA, Weitberg AB, Clark EP, Stossel TP. Phagocytes as carcinogens: malignant transformation produced by human neutrophils. Science 1985;227:1231–1233.
Shau H, Golub SH. Inhibition of lymphokine-activated killer- and natural killer-mediated cytotoxicities by neutrophils. J. Immunol 1989;143:1066–1072.
Remick SC, Hafez GR, Carbone PP. Extrapulmonary small-cell carcinoma. A review of the literature with emphasis on therapy and outcome. Medicine 1987;66:457–471.
Nishimura Y, Sekine T, Kobayashi T, Amikura K, Sakamoto H, Tanaka Y. Clinicopathological study of rare histological types of colorectal cancer-Multi institutional questionnaire study (in Japanese with English abstract). Nippon Daichokomonbyo Gakkai Zasshi (J Jpn Soc Coloproctol) 2004;3:132–140.
Orenstein JM, Schwartz AM. Small-cell undifferentiated carcinoma of the colorectum. Ultrastruct Pathol 1987;11:781–786.
Redman BG, Pazdur R. Colonic small cell undifferentiated carcinoma: a distant pathological diagnosis with therapeutic implications. Am J Gastroenterol 1987;82:382–385.
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335–2342.
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Matsuda, A., Sasajima, K., Matsutani, T. et al. Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: Report of a case. Surg Today 39, 990–993 (2009). https://doi.org/10.1007/s00595-008-3941-1
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DOI: https://doi.org/10.1007/s00595-008-3941-1