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Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus

  • Roberto Gambino
  • Giovanni Fanni
  • Gabriele Togliatto
  • Valentina Ponzo
  • Ilaria Goitre
  • Maurizio Cassader
  • Maria Felice BrizziEmail author
  • Simona BoEmail author
Short Communication

Introduction

Resveratrol is a polyphenolic compound found in several plants, such as Polygonum cuspidatum roots, peanuts, berries and red grapes [S1, Online-Resource-1]. In preclinical studies, resveratrol has been shown to act as an activator of Sirtuin-1 (SIRT1), a NAD+ histone deacetylase, member of the sirtuins family, which plays a crucial role, among others, in glucose metabolism, nutrient sensing and inflammation shutdown [S2]. The potential role of SIRT1 variants has been investigated in various dysmetabolic and inflammatory diseases [S3]; moreover, the relationship between several single nucleotide polymorphisms (SNPs) and SIRT1 expression has recently been explored [S4–S7].

The effects of resveratrol in humans are controversial [S8], probably due to the unfavorable pharmacokinetics (such as low bioavailability, influenced by food matrix and gut microbiota) and the lack of well-defined pharmacodynamics [1, S9–S12]. We recently failed to demonstrate resveratrol-associated...

Notes

Authors contributions

RG participated in the conception of the study, data analysis, interpretation of the findings of the study, manuscript writing and revision. GF participated in the data analysis, interpretation of the findings, manuscript writing and revision. GT participated in the data analysis, interpretation of the findings, and manuscript revision. VP participated in the data collection, interpretation of the findings and manuscript revision. IG participated in the data collection, interpretation of the findings and manuscript revision. MC participated in the design of the study, interpretation of the findings and manuscript revision. MFB participated in the conception of the study, data analysis, interpretation of the findings and manuscript revision. SB participated in the conception and design of the study, data collection and revision, manuscript writing and revision. All authors have approved the final article.

Funding

This study was supported by the Ministry of Health (Ricerca Sanitaria Finalizzata 2010; Grant Number RF-2010-2313155) and by the Ministry of Education, University and Research (PRIN 2010–2011 (Grant Number 2010JCWWKM_006)) of Italy. Sponsors had no involvement in the study design, the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the article for publication.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interests.

Ethical approval

All procedures respected the Helsinki Declaration principles. The study was approved by the local ethics committee.

Informed consent

All participants provided written informed consent.

Supplementary material

592_2019_1341_MOESM1_ESM.doc (58 kb)
Supplementary material 1 (DOC 66 kb)
592_2019_1341_MOESM2_ESM.doc (84 kb)
Supplementary material 2 (DOC 86 kb)

References

  1. 1.
    Bo S, Ponzo V, Ciccone G et al (2016) Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial. Pharmacol Res 111:896–905.  https://doi.org/10.1016/j.phrs.2016.08.010 CrossRefGoogle Scholar
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    Rai E, Sharma S, Kaul S et al (2012) The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population. PLoS ONE 7:7–12.  https://doi.org/10.1371/journal.pone.0048621 Google Scholar
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    Siedlinski M, Boer JMA, Smit HA et al (2012) Dietary factors and lung function in the general population: wine and resveratrol intake. Eur Respir J 39:385–391.  https://doi.org/10.1183/09031936.00184110 CrossRefGoogle Scholar
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    Figarska SM, Vonk JM, Boezen HM (2013) SIRT1 polymorphism, long-term survival and glucose tolerance in the general population. PLoS ONE 8:1–6.  https://doi.org/10.1371/journal.pone.0058636 Google Scholar
  5. 5.
    Bo S, Togliatto G, Gambino R et al (2018) Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation. Acta Diabetol 55:331–340.  https://doi.org/10.1007/s00592-017-1097-4 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medical SciencesUniversity of TurinTurinItaly

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