Rs12778366 single nucleotide polymorphism of Sirtuin 1 (SIRT1) and response to resveratrol supplementation in patients with type 2 diabetes mellitus
Resveratrol is a polyphenolic compound found in several plants, such as Polygonum cuspidatum roots, peanuts, berries and red grapes [S1, Online-Resource-1]. In preclinical studies, resveratrol has been shown to act as an activator of Sirtuin-1 (SIRT1), a NAD+ histone deacetylase, member of the sirtuins family, which plays a crucial role, among others, in glucose metabolism, nutrient sensing and inflammation shutdown [S2]. The potential role of SIRT1 variants has been investigated in various dysmetabolic and inflammatory diseases [S3]; moreover, the relationship between several single nucleotide polymorphisms (SNPs) and SIRT1 expression has recently been explored [S4–S7].
The effects of resveratrol in humans are controversial [S8], probably due to the unfavorable pharmacokinetics (such as low bioavailability, influenced by food matrix and gut microbiota) and the lack of well-defined pharmacodynamics [1, S9–S12]. We recently failed to demonstrate resveratrol-associated...
RG participated in the conception of the study, data analysis, interpretation of the findings of the study, manuscript writing and revision. GF participated in the data analysis, interpretation of the findings, manuscript writing and revision. GT participated in the data analysis, interpretation of the findings, and manuscript revision. VP participated in the data collection, interpretation of the findings and manuscript revision. IG participated in the data collection, interpretation of the findings and manuscript revision. MC participated in the design of the study, interpretation of the findings and manuscript revision. MFB participated in the conception of the study, data analysis, interpretation of the findings and manuscript revision. SB participated in the conception and design of the study, data collection and revision, manuscript writing and revision. All authors have approved the final article.
This study was supported by the Ministry of Health (Ricerca Sanitaria Finalizzata 2010; Grant Number RF-2010-2313155) and by the Ministry of Education, University and Research (PRIN 2010–2011 (Grant Number 2010JCWWKM_006)) of Italy. Sponsors had no involvement in the study design, the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the article for publication.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interests.
All procedures respected the Helsinki Declaration principles. The study was approved by the local ethics committee.
All participants provided written informed consent.