The impact of diabetes mellitus on clinical outcomes following chemotherapy for the patients with pancreatic cancer: a meta-analysis
A meta-analysis was performed to evaluate the prognostic impact of diabetes on the clinical outcome for patients with pancreatic cancer following the adjuvant chemotherapy.
To identify all researches and studies relevant to the prognostic impact of diabetes on the clinical outcome for patients with pancreatic cancer following the adjuvant chemotherapy, a comprehensive literature search was performed until January 30, 2018, by searching PubMed, EMBASE, and the Cochrane Library. The relevant data were extracted from included studies by two reviewers independently. HR and its 95% confidence interval (CI) were synthesized using STATA 12.0 software.
All of six studies consisting of 4241 pancreatic cancer patients (1034 patients with DM and 3207 patients without DM) were eligible and included in this meta-analysis. The result of meta-analysis under a fixed model showed that there are significant differences in overall survival (HR 1.16, 95% CI 1.08–1.25, P = 0.000) and T stage (OR 1.30, 95% CI 1.08–2.17, P = 0.005) between PC patients with DM following chemotherapy and PC patients without DM following chemotherapy. There was no significant difference in gender (OR 1.23, 95% CI 1.00–1.50, P = 0.051), tumor locations (OR 1.13, 95% CI 0.81–1.56, P = 0.476), cancer extent (OR 0.85, 95% CI 0.48–1.50, P = 0.569), N stage (OR 1.01, 95% CI 0.58–1.74, P = 0.973), and M stage (OR 0.64, 95% CI 0.21–1.99, P = 0.441) between diabetic PC patients and non-diabetic patients.
Diabetes mellitus patients who undergo chemotherapy for pancreatic cancer present with a reduced survival and lager tumor. Pancreatic cancer patients with DM also have a higher risk of death after chemotherapy.
KeywordsPancreatic cancer Diabetes mellitus Overall survival Meta-analysis
This study was supported by the National Natural Science Foundation of China (Grant No. 81560480), Health Science Research Program of Gansu Province (No. GSWSKY2016-19), and Ph.D. Science Research Foundation of Lanzhou University Second Hospital.
Compliance with ethical standards
Conflict of interest
All authors declare that there was no any conflict of interests in this article.
Statement of human and animal rights
This study is a meta-analysis of other studies where all procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.
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