Acta Diabetologica

, Volume 56, Issue 1, pp 127–128 | Cite as

Comment on “Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis”

  • Aldo BonaventuraEmail author
  • Fabrizio Montecucco
Letter to the Editor

Dear Editor,

We read with interest the research article by Apostolopoulou et al. recently published in Acta Diabetologica [1], in which authors investigated the potential association between circulating lymphocyte subsets and different stages of type 1 diabetes (T1D) [1]. Authors reported that, among patients with T1D, CD8+ cytotoxic T cells positively associated with a worse metabolic profile and the degree of inflammation, but not with insulin secretion in the 5 years following the diagnosis. The relationship between CD8+ T cells and impaired metabolic and inflammatory profiles is likely to reflect an immune process accounting for lower C-peptide levels at the time of T1D diagnosis. As well, the percentage of CD8+T cells did not correlate with glucagon-stimulated C-peptide concentration at 5 years, thus confirming the progressive reduction of the secretory function of β cell due to the progressive islet destruction. Finally, after 5 years from diagnosis, neutrophil count from T1D...



This study was supported by a Grant from the Rete Cardiologica from the Italian Ministry of Health to Fabrizio Montecucco.

Author contributions

AB and FM conceived the manuscript. AB wrote the manuscript draft. FM read critically and improved the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Human and animal rights

The authors declare that they have no competing interests.

Informed consent

For this type of study formal consent is not required.


  1. 1.
    Apostolopoulou M, Menart-Houtermans B, Ruetter R, Nowotny B, Gehrmann U, Markgraf D et al (2018) Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis. Acta Diabetol 55:723–731. CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.First Clinic of Internal Medicine, Department of Internal MedicineUniversity of GenoaGenoaItaly
  2. 2.IRCCS Ospedale Policlinico San MartinoGenoaItaly
  3. 3.Centre of Excellence for Biomedical Research (CEBR)University of GenoaGenoaItaly

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