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Aspirin versus rivaroxaban in postoperative bleeding after total knee arthroplasty: a retrospective case-matched study

  • Varah YuenyongviwatEmail author
  • Pakjai Tuntarattanapong
  • Chaiwat Chuaychoosakoon
  • Chavalit Iemsaengchairat
  • Khanin Iamthanaporn
  • Theerawit Hongnaparak
Original Article • KNEE - ARTHROPLASTY
  • 32 Downloads

Abstract

Background

Venous thromboembolic disease (VTE) is a complication not uncommon following total knee arthroplasty. Postoperative bleeding-related complications are a concern in many guidelines. The authors aimed to compare the amount of postoperative drainage from closed suction drainage, transfusion rate, and postoperative complications between aspirin and rivaroxaban as VTE prophylaxes after total knee arthroplasty.

Methods

This study was a retrospective case-matched study of 155 patients. The data were collected between 2008 and 2015 from patients who had total knee arthroplasty using aspirin or rivaroxaban as the VTE prophylaxis. Seventy-nine patients received aspirin, and 76 patients received rivaroxaban. A single surgeon operated on all patients with the same surgical technique and patient care protocol.

Results

The total closed suction drainage outputs at 48 h were not significantly different between the aspirin and rivaroxaban groups (p = 0.10). Eighteen percent of patients in the aspirin group and 25% of patients in the rivaroxaban group received blood transfusions (p = 0.37). There were no bleeding-related complications or VTE in either group.

Conclusions

Aspirin and rivaroxaban were effective and safe as VTE chemoprophylaxis in total knee arthroplasty.

Keywords

Total knee replacement Aspirin Rivaroxaban VTE 

Abbreviations

VTE

Venous thromboembolic disease

BMI

Body mass index (BMI)

ASA classification

The American Society of Anesthesiologists classification

Notes

Acknowledgements

The authors wish to thank Glenn Shingledecker for his assistance in proofreading the English of this report.

Authors’ contributions

VY designed the study and performed the analysis and manuscript preparation; TH designed the study and performed the data analysis; PT, CC, and CI collected data; KI designed the study and reviewed the manuscript. All authors read and approved the final manuscript.

Funding

Funding for this research was provided by the Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand (Grant No. 58-261-11-1).

Compliance with ethical standards

Conflict of interests

The authors declare that they have no competing interests.

Ethics approval

This study was approved by the Ethics Committee and Institutional Review Board of the Faculty of Medicine, Prince of Songkla University (EC 58-261-11-1).

Informed consent

Consent was waived by the ethics committee. The hospital gave permission to extract information from the database.

Availability of data and materials

The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Copyright information

© Springer-Verlag France SAS, part of Springer Nature 2019

Authors and Affiliations

  • Varah Yuenyongviwat
    • 1
    Email author return OK on get
  • Pakjai Tuntarattanapong
    • 1
  • Chaiwat Chuaychoosakoon
    • 1
  • Chavalit Iemsaengchairat
    • 2
  • Khanin Iamthanaporn
    • 1
  • Theerawit Hongnaparak
    • 1
  1. 1.Department of Orthopedics, Faculty of MedicinePrince of Songkla UniversityHat YaiThailand
  2. 2.Department of OrthopedicsRatchaburi HospitalRatchaburiThailand

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