Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty

  • Shane R. HessEmail author
  • Laura A. Lahaye
  • Andrew C. Waligora
  • Adam P. Sima
  • William A. Jiranek
  • Gregory J. Golladay
Original Article • KNEE- ARTHROPLASTY


Intrathecal morphine (ITM) can be useful for postoperative analgesia following lower extremity joint arthroplasty, but concerns exist regarding potential dose-related side effects. In this study, we examined the safety and efficacy of ITM in patients undergoing lower extremity joint arthroplasty. We hypothesized that there would be (1) direct relationship between dosing and side effects, and (2) an inverse relationship between ITM dosing and 24-hour postoperative opioid requirement.


Intrathecal morphine Neuraxial Anesthesia Spinal Arthroplasty Hip Knee 


Compliance with ethical standards

Conflicts of interest

Shane R. Hess, Laura A. Lahaye, Andrew C. Waligora, and Adam P. Sima have no conflicts of interest. William A. Jiranek discloses he is a paid consultant, receives royalties, had has stock with DePuy Synthes, and receives research support from DePuy Synthes and Stryker. Gregory J. Golladay discloses he is a paid consultant for OrthoSensor Inc., receives royalties and research support, has stock, and gives paid presentations for OrthoSensor Inc.; he is the deputy editor for Arthroplasty Today, on the editorial board for Journal of Arthroplasty, and is the publications committee chair for AAHKS.


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Copyright information

© Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  • Shane R. Hess
    • 1
    Email author
  • Laura A. Lahaye
    • 2
  • Andrew C. Waligora
    • 3
  • Adam P. Sima
    • 4
  • William A. Jiranek
    • 5
  • Gregory J. Golladay
    • 6
  1. 1.Department of Orthopedics, Center for Orthopedic Research and EducationThe CORE InstitutePhoenixUSA
  2. 2.Department of AnesthesiologyVirginia Commonwealth UniversityRichmondUSA
  3. 3.Greater Pittsburgh Orthopaedic AssociatesPittsburghUSA
  4. 4.Department of BiostatisticsVirginia Commonwealth UniversityRichmondUSA
  5. 5.Duke University Medical CenterDurhamUSA
  6. 6.Department of Orthopaedic SurgeryVirginia Commonwealth University Medical CenterRichmondUSA

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