Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)—Brazil
To investigate the association between plasma levels of inflammatory cytokines (interleukin [IL]-1-β, IL-6, tumor necrosis factor [TNF]-α, and the soluble TNF receptor 1 [sTNF-R1]), disability, and risk of falls in older women with acute low back pain (LBP).
This cross-sectional study comprised a subsample of older women from the Back Complaints in the Elders international cohort study. Plasma levels of IL-1-β, IL-6, TNF-α, and sTNF-R1 were measured using enzyme-linked immunosorbent assays. Pain was assessed using the Numerical Pain Scale and McGill Pain Questionnaire, while disability was measured using the Roland Morris Questionnaire and gait speed. Risk of falls was estimated using the Physiological Profile Assessment. Linear regression model was used to verify the association between independent variables and fall risk.
One hundred and ten women (aged 69.97 ± 5.5 years) with acute LBP were included. The regression model showed an association between the risk of falls and IL-6 levels, pain, gait speed, and years of education. It also explained 21.2% of risk of falls variance. The model equation was: fall risk = 1.28 + (0.19 IL-6) + (0.02 quality of pain) + (− 0.71 gait speed) + (−0 .17 educational level).
This study showed an association between risk of falls and IL-6, pain, gait speed, and educational level in older women with LBP.
KeywordsAging BACE Cytokines Disability Fall risk Low back pain
This study was funded by the National Council for Scientific and Technological Development, Brazil (152014/2016–0).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Murray CJL, Lopez AD (1996) Global and regional descriptive epidemiology of disability: incidence, prevalence, health expectancies and years lived with disability. In: The global burden of disease: a comprehensive assessment of moratlity and disability from diseasess, injuries and, risk factors in 1990 and projected to 2020. Global Burden of disease and injury, vol 1, Harvard School of Public Health, Boston, pp 201–246Google Scholar
- 3.Rosa NMB, Queiroz BZ, Lopes RA, Sampaio NR, Pereira DS, Pereira LSM (2016) Risk of falls in Brazilian elders with and without low back pain assessed using the Physiological Profile Assessment: BACE study. Braz J Phys Ther 20(6):502–509. https://doi.org/10.1590/bjpt-rbf.2014.0183 CrossRefPubMedPubMedCentralGoogle Scholar
- 5.Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Salvioli S (2007) Inflammaging and antiinflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Age Dev 128(1):92–105. https://doi.org/10.1016/j.mad.2006.11.016 CrossRefGoogle Scholar
- 7.Queiroz BZ, Pereira DS, Rosa NMB, Lopes RA, Felício DC, Pereira DAG, Dias JM, Dias RC, Pereira LSM (2015) Functional performance and plasma cytokine levels in elderly women with and without low back pain. J Back Musculoskelet Rehabil 28(2):343–349. https://doi.org/10.3233/BMR-140526 CrossRefPubMedGoogle Scholar
- 8.Queiroz BZ, Pereira DS, Felício DC, Lopes RA, Silva JP, Rosa NMB, Dias JMD, Dias RC, Lustosa LP, Pereira LSM et al (2016) Association between plasma levels of mediators of inflammation with pain and disability in the elderly with acute low back pain: data from the Back Complaints in the Elders (BACE)-Brazil study. Spine (Phila PA 1976) 41(3):197–203. https://doi.org/10.1097/BRS.0000000000001214 CrossRefGoogle Scholar
- 9.Queiroz BZ, Pereira DS, Rosa NMB, Lopes RA, Andrade AGP, Felício DC, Jardim RMFVS, Leopoldino AAO, Silva JP, Pereira LSM (2017) Inflammatory mediators and pain in the first year after acute episode of low-back pain in elderly women: longitudinal data from back complaints in the elders-Brazil. Am J Phys Med Rehabil 96(8):535–540. https://doi.org/10.1097/PHM.0000000000000661 CrossRefPubMedGoogle Scholar
- 14.Lord SR, Clark RD, Webster IW (1991) Physiological factors associated with falls in an elderly population. J Am Geriatr Soc 39(12):1194–1200. https://doi.org/10.1111/j.1532-5415.1991.tb03574.x CrossRefPubMedGoogle Scholar
- 16.Santos CC, Pereira LSM, Resende MA, Magno F, Aguiar V (2006) Applicability of the Brazilian version of the McGill pain questionnaire in elderly patients with chronic pain. Acta Fisiatr 13:75–82Google Scholar
- 17.Costa LOP, Maher CG, Latimer J, Ferreira PH, Pozzi GC, Ribeiro RN (2007) Psychometric characteristics of the brazilian-portuguese versions of the functional rating index and the roland morris disability questionnaire. Spine (Phila PA 1976) 32(17):1902–1907. https://doi.org/10.1097/BRS.0b013e31811eab33 CrossRefGoogle Scholar
- 20.Matsudo S, Araujo T, Matsudo V, Andrade D, Andrade E, Oliveira LC (2001) International Physical Activity Questionnaire (lPAq): study of validity and reliability in Brazil. Rev Bras Ativ Física Saúde 6:5–18Google Scholar
- 21.Ruhe A, Fejer R, Walder B (2011) Center of pressure excursion as a measure of balance performance in patients with non-specific low back pain compared to healthy controls: a systematic review of the literature. Eur Spine J 20(3):358–368. https://doi.org/10.1007/s00586-010-1543-2 CrossRefPubMedGoogle Scholar
- 24.Gomes GC, Teixeira LF, Fonseca BE, Freitas FAS, Fonseca MLM, Pacheco BD, Gonçalves MR, Caramelli P (2015) Age and education influence the performance of elderly women on the dual-task timed up and go test. Arq Neuropsiquiatr 73(3):187–193. https://doi.org/10.1590/0004-282X20140233 CrossRefGoogle Scholar
- 25.Weber KT, Jacobsen TD, Maidhof R, Virojanapa J, Overby C, Bloom O, Quraishi S, Levine M, Chahine NO (2015) Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. Curr Rev Musculoskelet Med 8(1):18–31. https://doi.org/10.1007/s12178-014-9253-8 CrossRefPubMedPubMedCentralGoogle Scholar