Advertisement

Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)—Brazil

  • Bárbara Zille de QueirozEmail author
  • Nayza Maciel de Britto Rosa
  • Daniele Sirineu Pereira
  • Renata Antunes Lopes
  • Amanda Aparecida Oliveira Leopoldino
  • Ronaldo Luiz Thomasini
  • Diogo Carvalho Felício
  • Lygia Paccini Lustosa
  • Leani Souza Máximo Pereira
Original Article

Abstract

Purpose

To investigate the association between plasma levels of inflammatory cytokines (interleukin [IL]-1-β, IL-6, tumor necrosis factor [TNF]-α, and the soluble TNF receptor 1 [sTNF-R1]), disability, and risk of falls in older women with acute low back pain (LBP).

Methods

This cross-sectional study comprised a subsample of older women from the Back Complaints in the Elders international cohort study. Plasma levels of IL-1-β, IL-6, TNF-α, and sTNF-R1 were measured using enzyme-linked immunosorbent assays. Pain was assessed using the Numerical Pain Scale and McGill Pain Questionnaire, while disability was measured using the Roland Morris Questionnaire and gait speed. Risk of falls was estimated using the Physiological Profile Assessment. Linear regression model was used to verify the association between independent variables and fall risk.

Results

One hundred and ten women (aged 69.97 ± 5.5 years) with acute LBP were included. The regression model showed an association between the risk of falls and IL-6 levels, pain, gait speed, and years of education. It also explained 21.2% of risk of falls variance. The model equation was: fall risk = 1.28 + (0.19 IL-6) + (0.02 quality of pain) + (− 0.71 gait speed) + (−0 .17 educational level).

Conclusions

This study showed an association between risk of falls and IL-6, pain, gait speed, and educational level in older women with LBP.

Graphic abstract

These slides can be retrieved under Electronic Supplementary Material.

Keywords

Aging BACE Cytokines Disability Fall risk Low back pain 

Notes

Acknowledgements

This study was funded by the National Council for Scientific and Technological Development, Brazil (152014/2016–0).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

586_2019_6168_MOESM1_ESM.pptx (209 kb)
Supplementary file1 (PPTX 209 kb)

References

  1. 1.
    Leopoldino AAO, Diz JBM, Martins VT, Henschkec N, Preira LSM, Dias RC, Oliveira VC (2016) Prevalence of low back pain in older Brazilians: asystematic review with meta-analysis. Braz J Rheumatol 56(3):258–269.  https://doi.org/10.1016/j.rbre.2016.03.011 CrossRefGoogle Scholar
  2. 2.
    Murray CJL, Lopez AD (1996) Global and regional descriptive epidemiology of disability: incidence, prevalence, health expectancies and years lived with disability. In: The global burden of disease: a comprehensive assessment of moratlity and disability from diseasess, injuries and, risk factors in 1990 and projected to 2020. Global Burden of disease and injury, vol 1, Harvard School of Public Health, Boston, pp 201–246Google Scholar
  3. 3.
    Rosa NMB, Queiroz BZ, Lopes RA, Sampaio NR, Pereira DS, Pereira LSM (2016) Risk of falls in Brazilian elders with and without low back pain assessed using the Physiological Profile Assessment: BACE study. Braz J Phys Ther 20(6):502–509.  https://doi.org/10.1590/bjpt-rbf.2014.0183 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Lord SR, Menz HB, Tiedemann A (2003) A physiological profile approach to falls risk assessment and prevention. Phys Ther 83(3):237–252.  https://doi.org/10.1093/ptj/83.3.237 CrossRefPubMedGoogle Scholar
  5. 5.
    Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Salvioli S (2007) Inflammaging and antiinflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Age Dev 128(1):92–105.  https://doi.org/10.1016/j.mad.2006.11.016 CrossRefGoogle Scholar
  6. 6.
    Cui JG, Holmin S, Meyerson BA, Linderoth B (2000) Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy. Pain 88(3):239–248CrossRefGoogle Scholar
  7. 7.
    Queiroz BZ, Pereira DS, Rosa NMB, Lopes RA, Felício DC, Pereira DAG, Dias JM, Dias RC, Pereira LSM (2015) Functional performance and plasma cytokine levels in elderly women with and without low back pain. J Back Musculoskelet Rehabil 28(2):343–349.  https://doi.org/10.3233/BMR-140526 CrossRefPubMedGoogle Scholar
  8. 8.
    Queiroz BZ, Pereira DS, Felício DC, Lopes RA, Silva JP, Rosa NMB, Dias JMD, Dias RC, Lustosa LP, Pereira LSM et al (2016) Association between plasma levels of mediators of inflammation with pain and disability in the elderly with acute low back pain: data from the Back Complaints in the Elders (BACE)-Brazil study. Spine (Phila PA 1976) 41(3):197–203.  https://doi.org/10.1097/BRS.0000000000001214 CrossRefGoogle Scholar
  9. 9.
    Queiroz BZ, Pereira DS, Rosa NMB, Lopes RA, Andrade AGP, Felício DC, Jardim RMFVS, Leopoldino AAO, Silva JP, Pereira LSM (2017) Inflammatory mediators and pain in the first year after acute episode of low-back pain in elderly women: longitudinal data from back complaints in the elders-Brazil. Am J Phys Med Rehabil 96(8):535–540.  https://doi.org/10.1097/PHM.0000000000000661 CrossRefPubMedGoogle Scholar
  10. 10.
    Cesari M, Penninx BW, Pahor M et al (2004) Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol Ser A Biol Sci Med Sci 59(3):242–248.  https://doi.org/10.1093/gerona/59.3.M242 CrossRefGoogle Scholar
  11. 11.
    Rosa NMB, Queiroz BZ, Pereira DS, Santos MLAS, Oliveira DMG, Narciso FMS, Pereira LSM (2011) Interleukin-6 plasma levels and socioeconomic status in Brazilian elderly community-dwelling women. Arch Gerontol Geriatr 53(2):196–199.  https://doi.org/10.1016/j.archger.2010.10.022 CrossRefGoogle Scholar
  12. 12.
    Scheele J, Luijsterburg PA, Ferreira ML, Maher CG, Pereira L, Peul WC, Koes BW (2011) Back complaints in the elders (BACE); design of cohort studies in primary care: an international consortium. BMC Musculoskelet Disord 19(12):193.  https://doi.org/10.1186/1471-2474-12-193 CrossRefGoogle Scholar
  13. 13.
    Brucki SMD, Nitrini R, Caramelli P, Bertolucci PHF, Okamoto IH (2003) Suggestions for utilization of the mini-mental state examination in Brazil. Arq Neuropsiquiatr 61(3B):777–781CrossRefGoogle Scholar
  14. 14.
    Lord SR, Clark RD, Webster IW (1991) Physiological factors associated with falls in an elderly population. J Am Geriatr Soc 39(12):1194–1200.  https://doi.org/10.1111/j.1532-5415.1991.tb03574.x CrossRefPubMedGoogle Scholar
  15. 15.
    Williamson A, Hoggart B (2005) Pain: a review of three commonly used pain rating scales. J Clin Nurs 14(7):798–804.  https://doi.org/10.1111/j.1365-2702.2005.01121.x CrossRefGoogle Scholar
  16. 16.
    Santos CC, Pereira LSM, Resende MA, Magno F, Aguiar V (2006) Applicability of the Brazilian version of the McGill pain questionnaire in elderly patients with chronic pain. Acta Fisiatr 13:75–82Google Scholar
  17. 17.
    Costa LOP, Maher CG, Latimer J, Ferreira PH, Pozzi GC, Ribeiro RN (2007) Psychometric characteristics of the brazilian-portuguese versions of the functional rating index and the roland morris disability questionnaire. Spine (Phila PA 1976) 32(17):1902–1907.  https://doi.org/10.1097/BRS.0b013e31811eab33 CrossRefGoogle Scholar
  18. 18.
    Vanswearinger JM, Brach JS (2001) Making geriatric assesment work: selecting useful measures. Phys Ther 81(6):1233–1252.  https://doi.org/10.1093/ptj/81.6.1233 CrossRefGoogle Scholar
  19. 19.
    Batistoni SST, Neri AL, Cupertino APFB (2007) Validity of the center for epidemiological studies depression scale among Brasilian elderly. Rev Saúde Públ 41(4):598–605.  https://doi.org/10.1590/S0034-89102007000400014 CrossRefGoogle Scholar
  20. 20.
    Matsudo S, Araujo T, Matsudo V, Andrade D, Andrade E, Oliveira LC (2001) International Physical Activity Questionnaire (lPAq): study of validity and reliability in Brazil. Rev Bras Ativ Física Saúde 6:5–18Google Scholar
  21. 21.
    Ruhe A, Fejer R, Walder B (2011) Center of pressure excursion as a measure of balance performance in patients with non-specific low back pain compared to healthy controls: a systematic review of the literature. Eur Spine J 20(3):358–368.  https://doi.org/10.1007/s00586-010-1543-2 CrossRefPubMedGoogle Scholar
  22. 22.
    David S, Blizzard L, Fell J, Jones G (2012) Prospective study self-reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community-dwelling older adults. Arthritis Care Res 64(1):30–37.  https://doi.org/10.1002/acr.20545 CrossRefGoogle Scholar
  23. 23.
    Fritz S, Lusardi M (2009) White paper: walking speed: the sixth vital sign. J Geriatr Phys Ther 32(2):46–49.  https://doi.org/10.1123/japa.2013-0236 CrossRefPubMedGoogle Scholar
  24. 24.
    Gomes GC, Teixeira LF, Fonseca BE, Freitas FAS, Fonseca MLM, Pacheco BD, Gonçalves MR, Caramelli P (2015) Age and education influence the performance of elderly women on the dual-task timed up and go test. Arq Neuropsiquiatr 73(3):187–193.  https://doi.org/10.1590/0004-282X20140233 CrossRefGoogle Scholar
  25. 25.
    Weber KT, Jacobsen TD, Maidhof R, Virojanapa J, Overby C, Bloom O, Quraishi S, Levine M, Chahine NO (2015) Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. Curr Rev Musculoskelet Med 8(1):18–31.  https://doi.org/10.1007/s12178-014-9253-8 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Bárbara Zille de Queiroz
    • 1
    Email author
  • Nayza Maciel de Britto Rosa
    • 1
  • Daniele Sirineu Pereira
    • 2
  • Renata Antunes Lopes
    • 1
  • Amanda Aparecida Oliveira Leopoldino
    • 1
  • Ronaldo Luiz Thomasini
    • 3
  • Diogo Carvalho Felício
    • 1
  • Lygia Paccini Lustosa
    • 1
  • Leani Souza Máximo Pereira
    • 1
  1. 1.Department of Physical Therapy, Post-Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational TherapyUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Department of Physical TherapyUniversidade Federal de AlfenasAlfenasBrazil
  3. 3.Universidade Federal Do Vale Do Jequitinhonha E MucuriDiamantinaBrazil

Personalised recommendations