Ameliorative effects of Mentha aquatica on diabetic and nephroprotective potential activities in STZ-induced renal injury

  • Prabhakar Yellanur Konda
  • Janardhan Yadav Egi
  • Sreenivasulu Dasari
  • Raju Katepogu
  • Krishna Kumar Jaiswal
  • Prabhusaran NagarajanEmail author
Original Article


Diabetes is a chronic metabolic disorder characterized by chronic hyperglycemia which causes secondary pathophysiological changes in multiple organ systems. Clinically used oralhypoglycemic agents are associated with a lot of side effects and high cost of treatment. As per ethnobotanical relevance, traditional medicines and natural products offer a valuable alternative to the oralhypoglycemic drugs. This study was hypothesized to evaluate the antidiabetic and nephroprotective activities of Mentha aquatica in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ at a dosage of 40 mg/kg bw. At the end of the study, overnight-fasted rats were dissected, and the blood and kidney samples were analyzed for biochemical and histopathological analysis. Oral administration of aqueous extract of leaves of Mentha aquatica (AELMA) at a dose of 100 mg/kg bw/day for 90 days significantly decreased the level of fasting blood glucose, HbA1c, TC, TG, plasma urea, creatinine, urine albumin, and kidney lipid peroxidation and increased the body weight, insulin, HDL cholesterol, plasma albumin, urinary urea, urinary creatinine, and antioxidant enzyme activities. The present study demonstrates that aqueous extract leaves of Mentha aquatica exert significant antidiabetic activity by stimulating secretion of insulin and nephroprotective potential activity by reducing the lipid peroxidation and enhancing the scavenging ability of antioxidant defense system in the body.


Mentha aquatica Streptozotocin Antidiabetic activity Nephroprotective activity 



We would like to acknowledge the anonymous referees for helpful comments and suggestions.

Author contributions

PN designed the study and wrote the original draft. YKP, JYE, SD, RK, and KKJ performed the experiments, are involved in data curation, and wrote the manuscript. YKP and PN reviewed and edited the paper.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Biochemistry, Krijan Biotech, MalleshwaramBangaloreIndia
  2. 2.Department of BiotechnologySri Venkateswara UniversityTirupatiIndia
  3. 3.Department of BiochemistrySri Venkateswara UniversityTirupatiIndia
  4. 4.Department of Science and HumanitiesSV College of Engineering (JNTUA)TirupatiIndia
  5. 5.Centre for Green Energy TechnologyPondicherry UniversityPuducherryIndia
  6. 6.Department of MicrobiologyTrichy SRM Medical College Hospital and Research CentreTiruchirapalliIndia

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