Comparative Clinical Pathology

, Volume 28, Issue 2, pp 467–471 | Cite as

SURGICEL compared with simple gauze packing in grade IV liver injury: an experimental study

  • Hadi Khoshmohabat
  • Shahram Paydar
  • Mohammad Yasin Karami
  • Alireza MakaremEmail author
  • Seyede Niloofar Dastgheib
  • Amirhosein Pourdavood
  • Hamid Reza Rasouli
Original Article


A number of hemostatic agents such as porcine collagen, topical thrombin, and SURGICEL (oxidized cellulose) can be used to achieve homeostasis in liver laceration. This study aims to compare stereological findings in using SURGICEL vs. gauze packing in grade 4 liver lacerations in Wistar rats. In this experimental study, 20 male Wistar-albino rats weighing 250–300 g were purchased from Shiraz University of Medical Sciences animal laboratory. At the beginning of the study, a 1-cm length and 0.5-cm depth linear laceration was made on the large lobe of the liver in all rats through laparotomy. At least one or more liver tissue samples were obtained from live rats to compare the efficacy of SURGICEL vs. gauze packing. According to our stereological results, normal liver tissue in the SURGICEL group (0.882 ± 0.146) was significantly lower than the controls (0.994 ± 0.007) (p value < .016). Liver fibrosis in the SURGICEL group (0.043 ± 0.025) was significantly more than the control group (0.005 ± 0.007) (p value < .016). As known, by increase in the fibrosis tissue, the chance of recurrent bleeding decreases; analysis of the results showed that we had more fibrosis tissue after treatment of liver laceration by SURGICEL instead of gauze and it is a new hope in liver laceration treatment methods.


SURGICEL Liver injury Hemostatic agent Gauze packing 



The authors would like to acknowledge the Research Center of Shiraz University of Medical Science for improving the use of English in the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Ethics number: ir.bmsu.rec.1396.418.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  • Hadi Khoshmohabat
    • 1
  • Shahram Paydar
    • 2
  • Mohammad Yasin Karami
    • 2
  • Alireza Makarem
    • 1
    • 3
    Email author
  • Seyede Niloofar Dastgheib
    • 2
  • Amirhosein Pourdavood
    • 4
  • Hamid Reza Rasouli
    • 1
  1. 1.Trauma Research CenterBaqiyatallah University of Medical SciencesTehranIran
  2. 2.Trauma Research CenterShiraz University of Medical SciencesShirazIran
  3. 3.Department of UrologyShiraz University of Medical SciencesShirazIran
  4. 4.Department of SurgeryKerman University of Medical SciencesKermanIran

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